evidence table

Collagen Joint Pain Randomized Trial Evidence Table

Structured evidence table for Collagen Joint Pain Randomized Trial, generated from 3 reusable source documents in the Migaku knowledge base.

topicclaimevidence levelcitationsource
Collagen Joint Pain Randomized TrialIn 2020, OA was a top-ten leading cause of years lived with disability (YLD), and its prevalence is expected to rise as a result of the increase in life expectancy, becoming a major socioeconomic and public health issue [–].2Möller Ingrid (2026)Efficacy and tolerability of native (undenatured) type II collagen supplementation for joint health in healthy volunteers: a randomized double-blind placebo-controlled study
Collagen Joint Pain Randomized TrialThis context has expanded the focus of research towards the risk factors of OA [].2Möller Ingrid (2026)Efficacy and tolerability of native (undenatured) type II collagen supplementation for joint health in healthy volunteers: a randomized double-blind placebo-controlled study
Collagen Joint Pain Randomized TrialJoint loading has been associated with synovial inflammation [], which has been suggested to play a role in the onset and structural progression of OA [].2Möller Ingrid (2026)Efficacy and tolerability of native (undenatured) type II collagen supplementation for joint health in healthy volunteers: a randomized double-blind placebo-controlled study
Collagen Joint Pain Randomized Trial1 1 3 Osteoarthritis (OA) is the most common joint disorder affecting up to 14.8% of the global population older than 30 years [].2Möller Ingrid (2026)Efficacy and tolerability of native (undenatured) type II collagen supplementation for joint health in healthy volunteers: a randomized double-blind placebo-controlled study
Collagen Joint Pain Randomized TrialThe most recent reports have indicated that worldwide prevalence rates have dramatically increased by 113.25% over the past 20 years [].3Vázquez-Del Mercado Mónica (2026)Managing Osteoarthritis Pain in Underrepresented Populations: Insights from Mexico and Latin America
Collagen Joint Pain Randomized TrialThe highest prevalence rate has been observed in Latin America, which increased by 203.56% from 1990 to 2019 [].3Vázquez-Del Mercado Mónica (2026)Managing Osteoarthritis Pain in Underrepresented Populations: Insights from Mexico and Latin America
Collagen Joint Pain Randomized TrialOA pain severity has also been associated with several comorbidities such as obesity, hypertension, osteoporosis, and emotional distress such as anxiety and depression [,,].3Vázquez-Del Mercado Mónica (2026)Managing Osteoarthritis Pain in Underrepresented Populations: Insights from Mexico and Latin America
Collagen Joint Pain Randomized Trial1 2 3 4 4 5 6 7 8 9 6 10 9 11 12 13 14 15 16 17 18 19 4 10 20 Osteoarthritis (OA) is the most common form of arthritis affecting the elderly population [,,].3Vázquez-Del Mercado Mónica (2026)Managing Osteoarthritis Pain in Underrepresented Populations: Insights from Mexico and Latin America
Collagen Joint Pain Randomized TrialIt causes chronic pain, reduced mobility, and disability, affecting 607 million individuals worldwide, with nearly 46.6 million new cases annually [].4Muacevic Alexander (2026)Evidence-Based Use of Undenatured Type II Collagen in the Management of Osteoarthritis in the Indian Subcontinent and Southeast Asia: A Narrative Review and an Expert Opinion
Collagen Joint Pain Randomized Trial11 12 13 14 15 11 15 HLA-DRB1 HLA-DQB1 Genetic polymorphisms in sterol regulatory element-binding protein 2 (rs2228314) [], interleukin-6 (rs1800795) [], and resistin (RETN) [] in Indian and Pakistani cohorts and growth differentiation factor 5 (rs143383) [],, andin Thai populations [] are linked to OA risk.4Muacevic Alexander (2026)Evidence-Based Use of Undenatured Type II Collagen in the Management of Osteoarthritis in the Indian Subcontinent and Southeast Asia: A Narrative Review and an Expert Opinion
Collagen Joint Pain Randomized TrialNeed for expert opinion Despite growing clinical and mechanistic evidence for collagen supplementation in OA, several gaps and challenges remain in translating this knowledge into clinical practice, especially in the Indian subcontinent and Southeast Asia.4Muacevic Alexander (2026)Evidence-Based Use of Undenatured Type II Collagen in the Management of Osteoarthritis in the Indian Subcontinent and Southeast Asia: A Narrative Review and an Expert Opinion
Collagen Joint Pain Randomized Trial1 2 3 4 6 7 8 9 10 1 Osteoarthritis (OA) is the most prevalent degenerative joint disease globally and the second most common rheumatologic condition [].4Muacevic Alexander (2026)Evidence-Based Use of Undenatured Type II Collagen in the Management of Osteoarthritis in the Indian Subcontinent and Southeast Asia: A Narrative Review and an Expert Opinion
topicCollagen Joint Pain Randomized Trial
claimIn 2020, OA was a top-ten leading cause of years lived with disability (YLD), and its prevalence is expected to rise as a result of the increase in life expectancy, becoming a major socioeconomic and public health issue [–].
evidence level2
citationMöller Ingrid (2026)
sourceEfficacy and tolerability of native (undenatured) type II collagen supplementation for joint health in healthy volunteers: a randomized double-blind placebo-controlled study
topicCollagen Joint Pain Randomized Trial
claimThis context has expanded the focus of research towards the risk factors of OA [].
evidence level2
citationMöller Ingrid (2026)
sourceEfficacy and tolerability of native (undenatured) type II collagen supplementation for joint health in healthy volunteers: a randomized double-blind placebo-controlled study
topicCollagen Joint Pain Randomized Trial
claimJoint loading has been associated with synovial inflammation [], which has been suggested to play a role in the onset and structural progression of OA [].
evidence level2
citationMöller Ingrid (2026)
sourceEfficacy and tolerability of native (undenatured) type II collagen supplementation for joint health in healthy volunteers: a randomized double-blind placebo-controlled study
topicCollagen Joint Pain Randomized Trial
claim1 1 3 Osteoarthritis (OA) is the most common joint disorder affecting up to 14.8% of the global population older than 30 years [].
evidence level2
citationMöller Ingrid (2026)
sourceEfficacy and tolerability of native (undenatured) type II collagen supplementation for joint health in healthy volunteers: a randomized double-blind placebo-controlled study
topicCollagen Joint Pain Randomized Trial
claimThe most recent reports have indicated that worldwide prevalence rates have dramatically increased by 113.25% over the past 20 years [].
evidence level3
citationVázquez-Del Mercado Mónica (2026)
sourceManaging Osteoarthritis Pain in Underrepresented Populations: Insights from Mexico and Latin America
topicCollagen Joint Pain Randomized Trial
claimThe highest prevalence rate has been observed in Latin America, which increased by 203.56% from 1990 to 2019 [].
evidence level3
citationVázquez-Del Mercado Mónica (2026)
sourceManaging Osteoarthritis Pain in Underrepresented Populations: Insights from Mexico and Latin America
topicCollagen Joint Pain Randomized Trial
claimOA pain severity has also been associated with several comorbidities such as obesity, hypertension, osteoporosis, and emotional distress such as anxiety and depression [,,].
evidence level3
citationVázquez-Del Mercado Mónica (2026)
sourceManaging Osteoarthritis Pain in Underrepresented Populations: Insights from Mexico and Latin America
topicCollagen Joint Pain Randomized Trial
claim1 2 3 4 4 5 6 7 8 9 6 10 9 11 12 13 14 15 16 17 18 19 4 10 20 Osteoarthritis (OA) is the most common form of arthritis affecting the elderly population [,,].
evidence level3
citationVázquez-Del Mercado Mónica (2026)
sourceManaging Osteoarthritis Pain in Underrepresented Populations: Insights from Mexico and Latin America
topicCollagen Joint Pain Randomized Trial
claimIt causes chronic pain, reduced mobility, and disability, affecting 607 million individuals worldwide, with nearly 46.6 million new cases annually [].
evidence level4
citationMuacevic Alexander (2026)
sourceEvidence-Based Use of Undenatured Type II Collagen in the Management of Osteoarthritis in the Indian Subcontinent and Southeast Asia: A Narrative Review and an Expert Opinion
topicCollagen Joint Pain Randomized Trial
claim11 12 13 14 15 11 15 HLA-DRB1 HLA-DQB1 Genetic polymorphisms in sterol regulatory element-binding protein 2 (rs2228314) [], interleukin-6 (rs1800795) [], and resistin (RETN) [] in Indian and Pakistani cohorts and growth differentiation factor 5 (rs143383) [],, andin Thai populations [] are linked to OA risk.
evidence level4
citationMuacevic Alexander (2026)
sourceEvidence-Based Use of Undenatured Type II Collagen in the Management of Osteoarthritis in the Indian Subcontinent and Southeast Asia: A Narrative Review and an Expert Opinion
topicCollagen Joint Pain Randomized Trial
claimNeed for expert opinion Despite growing clinical and mechanistic evidence for collagen supplementation in OA, several gaps and challenges remain in translating this knowledge into clinical practice, especially in the Indian subcontinent and Southeast Asia.
evidence level4
citationMuacevic Alexander (2026)
sourceEvidence-Based Use of Undenatured Type II Collagen in the Management of Osteoarthritis in the Indian Subcontinent and Southeast Asia: A Narrative Review and an Expert Opinion
topicCollagen Joint Pain Randomized Trial
claim1 2 3 4 6 7 8 9 10 1 Osteoarthritis (OA) is the most prevalent degenerative joint disease globally and the second most common rheumatologic condition [].
evidence level4
citationMuacevic Alexander (2026)
sourceEvidence-Based Use of Undenatured Type II Collagen in the Management of Osteoarthritis in the Indian Subcontinent and Southeast Asia: A Narrative Review and an Expert Opinion

Learn next

Related evidence and supplement guides

SupplementCollagen PeptidesHydrolysed collagen that stimulates fibroblasts — evidence for joints, skin elasticity, and tend...SupplementCollagenThe primary structural protein in the body, essential for skin elasticity, joint health, and str...GuideCollagen Joint Pain Randomized Trial: What the Evidence SaysCollagen Joint Pain Randomized Trial has 3 source documents in the current Migaku evidence datab...GuideHyaluronic Joint Pain Randomized Trial: What the Evidence SaysHyaluronic Joint Pain Randomized Trial has 2 source documents in the current Migaku evidence dat...GuideCollagen Joint Mobility Randomized Trial: What the Evidence SaysCollagen Joint Mobility Randomized Trial has 2 source documents in the current Migaku evidence d...GuideCollagen Joint Flexibility Randomized Trial: What the Evidence SaysCollagen Joint Flexibility Randomized Trial has 2 source documents in the current Migaku evidenc...CompareCollagen Peptides vs Collagen PowderWhile both forms offer collagen structure, Collagen Peptides are enzymatic broken down into smal...CompareCollagen Types I+III vs Collagen Type IIType I+III collagen supports skin and connective tissue, while Type II targets joint cartilage s...

Source documents

  1. Efficacy and tolerability of native (undenatured) type II collagen supplementation for joint health in healthy volunteers: a randomized double-blind placebo-controlled study
  2. Managing Osteoarthritis Pain in Underrepresented Populations: Insights from Mexico and Latin America
  3. Evidence-Based Use of Undenatured Type II Collagen in the Management of Osteoarthritis in the Indian Subcontinent and Southeast Asia: A Narrative Review and an Expert Opinion