joint health

Collagen Joint Discomfort Randomized Trial Evidence Table

Structured evidence table for Collagen Joint Discomfort Randomized Trial, generated from 2 reusable source documents in the Migaku knowledge base.

topicclaimevidence levelcitationsource
Collagen Joint Discomfort Randomized TrialIn 2020, OA was a top-ten leading cause of years lived with disability (YLD), and its prevalence is expected to rise as a result of the increase in life expectancy, becoming a major socioeconomic and public health issue [–].2Möller Ingrid (2026)Efficacy and tolerability of native (undenatured) type II collagen supplementation for joint health in healthy volunteers: a randomized double-blind placebo-controlled study
Collagen Joint Discomfort Randomized TrialThis context has expanded the focus of research towards the risk factors of OA [].2Möller Ingrid (2026)Efficacy and tolerability of native (undenatured) type II collagen supplementation for joint health in healthy volunteers: a randomized double-blind placebo-controlled study
Collagen Joint Discomfort Randomized TrialJoint loading has been associated with synovial inflammation [], which has been suggested to play a role in the onset and structural progression of OA [].2Möller Ingrid (2026)Efficacy and tolerability of native (undenatured) type II collagen supplementation for joint health in healthy volunteers: a randomized double-blind placebo-controlled study
Collagen Joint Discomfort Randomized Trial1 1 3 Osteoarthritis (OA) is the most common joint disorder affecting up to 14.8% of the global population older than 30 years [].2Möller Ingrid (2026)Efficacy and tolerability of native (undenatured) type II collagen supplementation for joint health in healthy volunteers: a randomized double-blind placebo-controlled study
Collagen Joint Discomfort Randomized TrialResults Within the AMS group, SLSD step count increased significantly by 16.83% (Δ = +12.78 steps; p p p Conclusions 12 weeks of AMS supplementation was associated with improvements in selected functional, mobility, and outcomes in generally healthy adults with self-reported knee discomfort.4Zhuang SR (2026)Evaluation of the Effect of <i>Astragalus membranaceus</i> Saponins Administration on Knee Function and Cartilage Biomarkers in Healthy Subjects with Knee Discomfort.
Collagen Joint Discomfort Randomized TrialAMS was also associated with changes in selected circulating biomarkers related to inflammation and cartilage metabolism.4Zhuang SR (2026)Evaluation of the Effect of <i>Astragalus membranaceus</i> Saponins Administration on Knee Function and Cartilage Biomarkers in Healthy Subjects with Knee Discomfort.
Collagen Joint Discomfort Randomized TrialObjective This study aimed to evaluate the effects of 12 weeks of Astragalus membranaceus saponins (AMS) supplementation on functional performance, knee joint mobility, self-reported outcomes, and biomarkers of inflammation and cartilage in healthy subjects with knee discomfort.4Zhuang SR (2026)Evaluation of the Effect of <i>Astragalus membranaceus</i> Saponins Administration on Knee Function and Cartilage Biomarkers in Healthy Subjects with Knee Discomfort.
Collagen Joint Discomfort Randomized TrialMethods A randomized, double-blind, placebo-controlled trial was conducted in healthy subjects aged 20-70 years with knee discomfort but without clinically diagnosed knee osteoarthritis.4Zhuang SR (2026)Evaluation of the Effect of <i>Astragalus membranaceus</i> Saponins Administration on Knee Function and Cartilage Biomarkers in Healthy Subjects with Knee Discomfort.
topicCollagen Joint Discomfort Randomized Trial
claimIn 2020, OA was a top-ten leading cause of years lived with disability (YLD), and its prevalence is expected to rise as a result of the increase in life expectancy, becoming a major socioeconomic and public health issue [–].
evidence level2
citationMöller Ingrid (2026)
sourceEfficacy and tolerability of native (undenatured) type II collagen supplementation for joint health in healthy volunteers: a randomized double-blind placebo-controlled study
topicCollagen Joint Discomfort Randomized Trial
claimThis context has expanded the focus of research towards the risk factors of OA [].
evidence level2
citationMöller Ingrid (2026)
sourceEfficacy and tolerability of native (undenatured) type II collagen supplementation for joint health in healthy volunteers: a randomized double-blind placebo-controlled study
topicCollagen Joint Discomfort Randomized Trial
claimJoint loading has been associated with synovial inflammation [], which has been suggested to play a role in the onset and structural progression of OA [].
evidence level2
citationMöller Ingrid (2026)
sourceEfficacy and tolerability of native (undenatured) type II collagen supplementation for joint health in healthy volunteers: a randomized double-blind placebo-controlled study
topicCollagen Joint Discomfort Randomized Trial
claim1 1 3 Osteoarthritis (OA) is the most common joint disorder affecting up to 14.8% of the global population older than 30 years [].
evidence level2
citationMöller Ingrid (2026)
sourceEfficacy and tolerability of native (undenatured) type II collagen supplementation for joint health in healthy volunteers: a randomized double-blind placebo-controlled study
topicCollagen Joint Discomfort Randomized Trial
claimResults Within the AMS group, SLSD step count increased significantly by 16.83% (Δ = +12.78 steps; p p p Conclusions 12 weeks of AMS supplementation was associated with improvements in selected functional, mobility, and outcomes in generally healthy adults with self-reported knee discomfort.
evidence level4
citationZhuang SR (2026)
sourceEvaluation of the Effect of <i>Astragalus membranaceus</i> Saponins Administration on Knee Function and Cartilage Biomarkers in Healthy Subjects with Knee Discomfort.
topicCollagen Joint Discomfort Randomized Trial
claimAMS was also associated with changes in selected circulating biomarkers related to inflammation and cartilage metabolism.
evidence level4
citationZhuang SR (2026)
sourceEvaluation of the Effect of <i>Astragalus membranaceus</i> Saponins Administration on Knee Function and Cartilage Biomarkers in Healthy Subjects with Knee Discomfort.
topicCollagen Joint Discomfort Randomized Trial
claimObjective This study aimed to evaluate the effects of 12 weeks of Astragalus membranaceus saponins (AMS) supplementation on functional performance, knee joint mobility, self-reported outcomes, and biomarkers of inflammation and cartilage in healthy subjects with knee discomfort.
evidence level4
citationZhuang SR (2026)
sourceEvaluation of the Effect of <i>Astragalus membranaceus</i> Saponins Administration on Knee Function and Cartilage Biomarkers in Healthy Subjects with Knee Discomfort.
topicCollagen Joint Discomfort Randomized Trial
claimMethods A randomized, double-blind, placebo-controlled trial was conducted in healthy subjects aged 20-70 years with knee discomfort but without clinically diagnosed knee osteoarthritis.
evidence level4
citationZhuang SR (2026)
sourceEvaluation of the Effect of <i>Astragalus membranaceus</i> Saponins Administration on Knee Function and Cartilage Biomarkers in Healthy Subjects with Knee Discomfort.

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Source documents

  1. Efficacy and tolerability of native (undenatured) type II collagen supplementation for joint health in healthy volunteers: a randomized double-blind placebo-controlled study
  2. Evaluation of the Effect of <i>Astragalus membranaceus</i> Saponins Administration on Knee Function and Cartilage Biomarkers in Healthy Subjects with Knee Discomfort.