topicCollagen Hair Nails Randomized Trial
claimIts decline is directly associated with cutaneous dehydration, underscoring its vital function in maintaining skin hydration.
evidence level2
citationGonzález-Rodríguez Yaiza (2026)
sourceComparative effects of MKARE® eggshell membrane and hydrolyzed collagen as nutricosmetics on skin biophysical properties: a randomized clinical trial
topicCollagen Hair Nails Randomized Trial
claimSuch supplementation has been associated with multiple benefits, including the prevention of sagging and stretch marks, improved skin elasticity and hydration, stimulation of collagen synthesis, strengthening of connective tissues, cartilage, bones, and muscles, reduction in visible signs of aging, and promotion of cellular regeneration ().
evidence level2
citationGonzález-Rodríguez Yaiza (2026)
sourceComparative effects of MKARE® eggshell membrane and hydrolyzed collagen as nutricosmetics on skin biophysical properties: a randomized clinical trial
topicCollagen Hair Nails Randomized Trial
claim64.60 ± 2.89; < 0.01) was found in the MKARE® group after 28 days compared to the baseline measurements.
evidence level2
citationGonzález-Rodríguez Yaiza (2026)
sourceComparative effects of MKARE® eggshell membrane and hydrolyzed collagen as nutricosmetics on skin biophysical properties: a randomized clinical trial
topicCollagen Hair Nails Randomized Trial
claimin vivo 1 The skin, serving as the first protective barrier of the body, possesses a complex mechanical structure.
evidence level2
citationGonzález-Rodríguez Yaiza (2026)
sourceComparative effects of MKARE® eggshell membrane and hydrolyzed collagen as nutricosmetics on skin biophysical properties: a randomized clinical trial
topicCollagen Hair Nails Randomized Trial
claimThe aim of this narrative review is to evaluate the evidence for several of the most common supplements for hair, skin, and nails, as well as potential concerns.
evidence level3
citationShing Vivian (2025)
sourceBenefits and risks of hair, skin, and nail supplements in older adults
topicCollagen Hair Nails Randomized Trial
claimMay result in copper deficiency.Excess zinc may also interfere with the efficacy of medications such as antibiotics DHEA Increases skin hydration and thickness Limited data to ascertain if the benefits outweigh the risks 7 25 to 50 mg/d in older participants Increase in testosterone may cause hirsutism and acne.
evidence level3
citationShing Vivian (2025)
sourceBenefits and risks of hair, skin, and nail supplements in older adults
topicCollagen Hair Nails Randomized Trial
claim9 10 9 Biotin can be naturally found in foods such as egg yolk, liver, cereals, vegetables, and rice.Biotin is also created as a byproduct by bacteria in the gut microbiome.For adults, the Food and Nutrition Board of the Institute of Medicine recommends a dietary intake of 30 mcg/d.
evidence level3
citationShing Vivian (2025)
sourceBenefits and risks of hair, skin, and nail supplements in older adults
topicCollagen Hair Nails Randomized Trial
claim1 2 Patients often seek advice for skin changes caused by years of sun exposure, nutrient deficiencies, genetics, and other factors.
evidence level3
citationShing Vivian (2025)
sourceBenefits and risks of hair, skin, and nail supplements in older adults