Structured evidence table for Collagen Exercise Performance Randomized Trial, generated from 2 reusable source documents in the Migaku knowledge base.
| topic | claim | evidence level | citation | source |
|---|---|---|---|---|
| Collagen Exercise Performance Randomized Trial | We consolidate mechanistic evidence, highlight discrepancies, and contextualize findings within the paradigm of physiological aging and preventive, non-therapeutic nutritional strategies for healthy aging. | 3 | Xiong Chunzi (2026) | The triad of collagen, vitamin C, and vitamin E in aging: emerging roles in mood and psychological health, neurotrophic support, cognitive function, endurance, and sarcopenia |
| Collagen Exercise Performance Randomized Trial | It is important to note that this triad is primarily considered as a prophylactic measure to maintain muscle mass, strength, and overall function, rather than a proven therapeutic intervention for established sarcopenia, and that most evidence derives from short-term or biomarker-based studies rather than longitudinal functional outcomes. | 3 | Xiong Chunzi (2026) | The triad of collagen, vitamin C, and vitamin E in aging: emerging roles in mood and psychological health, neurotrophic support, cognitive function, endurance, and sarcopenia |
| Collagen Exercise Performance Randomized Trial | Mitochondrial dysfunction serves as a pivotal catalyst in this phenomenon, as age-associated deficits in the efficiency of the electron transport chain escalate electron leakage and ROS production (). | 3 | Xiong Chunzi (2026) | The triad of collagen, vitamin C, and vitamin E in aging: emerging roles in mood and psychological health, neurotrophic support, cognitive function, endurance, and sarcopenia |
| Collagen Exercise Performance Randomized Trial | 1–4 5 6 7 8 9 10 11 12 Aging is characterized by progressive declines across various physiological systems, which encompass skeletal muscle, metabolic regulation, vascular integrity, hepatic function, immune competence, redox homeostasis, and cognitive performance. | 3 | Xiong Chunzi (2026) | The triad of collagen, vitamin C, and vitamin E in aging: emerging roles in mood and psychological health, neurotrophic support, cognitive function, endurance, and sarcopenia |
| Collagen Exercise Performance Randomized Trial | 1 Aging is characterized by progressive physiological decline, including loss of skeletal muscle mass and function (Sarcopenia), reduced mitochondrial efficiency, and increased oxidative stress, all of which contribute to frailty and diminished quality of life in older adults (). | 3 | Wang Xiaolan (2026) | Glycine and N-acetylcysteine supplementation, with or without exercise, in brain health and functional aging: implications for sarcopenia and frailty in older adults |
| Collagen Exercise Performance Randomized Trial | 1 2 3 4 5 By the age of 70, individuals may experience a 25%−30% reduction in muscle mass, which is strongly associated with impaired mobility, falls, and loss of independence (). | 3 | Wang Xiaolan (2026) | Glycine and N-acetylcysteine supplementation, with or without exercise, in brain health and functional aging: implications for sarcopenia and frailty in older adults |
| Collagen Exercise Performance Randomized Trial | Low circulating glycine levels have been associated with insulin resistance, obesity, and higher cardiometabolic risk (,). | 3 | Wang Xiaolan (2026) | Glycine and N-acetylcysteine supplementation, with or without exercise, in brain health and functional aging: implications for sarcopenia and frailty in older adults |
| Collagen Exercise Performance Randomized Trial | In this review, the term “older adults” generally refers to individuals aged ≥60 or ≥65 years, consistent with definitions used by the World Health Organization and most geriatric clinical trials. | 3 | Wang Xiaolan (2026) | Glycine and N-acetylcysteine supplementation, with or without exercise, in brain health and functional aging: implications for sarcopenia and frailty in older adults |
Source documents