Structured evidence table for Cocoa Flavanols Sleep Randomized Trial, generated from 3 reusable source documents in the Migaku knowledge base.
| topic | claim | evidence level | citation | source |
|---|---|---|---|---|
| Cocoa Flavanols Sleep Randomized Trial | Polyphenols strengthen the intestinal barrier and reduce endotoxemia; cocoa bean shell extracts protected against oxysterol‐induced intestinal damage and improved gut microbiota composition in preclinical models (Alia et al. ). | 3 | Akif Adnan (2026) | Dietary Polyphenols in Non‐Communicable Chronic Diseases: Neuro–Enteric Mechanisms, Multi‐Omics Biomarkers and Translational Opportunities |
| Cocoa Flavanols Sleep Randomized Trial | While many epidemiological studies correlate polyphenol‐rich diets (e.g., Mediterranean diet) with reduced NCCD risk, causality is uncertain due to confounding and measurement error. | 3 | Akif Adnan (2026) | Dietary Polyphenols in Non‐Communicable Chronic Diseases: Neuro–Enteric Mechanisms, Multi‐Omics Biomarkers and Translational Opportunities |
| Cocoa Flavanols Sleep Randomized Trial | Controlled trials provide more robust evidence but vary widely in doses, formulations, populations and endpoints. | 3 | Akif Adnan (2026) | Dietary Polyphenols in Non‐Communicable Chronic Diseases: Neuro–Enteric Mechanisms, Multi‐Omics Biomarkers and Translational Opportunities |
| Cocoa Flavanols Sleep Randomized Trial | AMP BBB CNS COMT COSMOS CRP (hs‐CRP) CSF EGCG ENB‐2 (ENB) ENS EVOO FMD GAD‐7 (GAD) GM‐CSF (GM) HDL HOMA‐IR (HOMA) IBS IL IR LDL LPS MCI MMSE NADPH NCCD (NCCDs) PHGG PHQ‐9 (PHQ) PSQI PWV RBANS RCT SCFA SD TNF (TNF‐α) 2024 Non‐communicable chronic diseases account for the majority of morbidity and mortality worldwide. | 3 | Akif Adnan (2026) | Dietary Polyphenols in Non‐Communicable Chronic Diseases: Neuro–Enteric Mechanisms, Multi‐Omics Biomarkers and Translational Opportunities |
| Cocoa Flavanols Sleep Randomized Trial | MetS is a multifactorial condition, with its primary indicators including obesity, hypertension, dyslipidemia, insulin resistance, and hyperglycemia; i.e., a patient who possesses at least 3 of the following parameters is designated with MetS: glucose intolerance, increased levels of triglycerides, augmented waist circumference, low levels of high-density lipoprotein cholesterol (HDL-c), and hypertension [,,]. | 3 | Tomaru Júlia Mayumi (2026) | Beyond Taste: The Impact of Chocolate on Cardiovascular and Steatotic Liver Disease Risk Factors |
| Cocoa Flavanols Sleep Randomized Trial | It is possible to develop a close relationship with MetS, metabolic dysfunction-associated steatotic liver disease (MASLD), and CVD [,]. | 3 | Tomaru Júlia Mayumi (2026) | Beyond Taste: The Impact of Chocolate on Cardiovascular and Steatotic Liver Disease Risk Factors |
| Cocoa Flavanols Sleep Randomized Trial | MASLD is strongly associated with various conditions, including MetS, and is characterized by the persistence of a chronic inflammatory state detrimental to the organism [,]. | 3 | Tomaru Júlia Mayumi (2026) | Beyond Taste: The Impact of Chocolate on Cardiovascular and Steatotic Liver Disease Risk Factors |
| Cocoa Flavanols Sleep Randomized Trial | 1 2 3 4 5 6 7 8 9 10 11 12 13 14 Metabolic disorders are increasing sharply due to severe modifications in lifestyle [,,,]. | 3 | Tomaru Júlia Mayumi (2026) | Beyond Taste: The Impact of Chocolate on Cardiovascular and Steatotic Liver Disease Risk Factors |
| Cocoa Flavanols Sleep Randomized Trial | Dietary patterns have emerged as modifiable risk factors that may influence disease onset and progression. | 4 | Fekete M (2025) | Mediterranean Diet, Polyphenols, and Neuroprotection: Mechanistic Insights into Resveratrol and Oleuropein. |
| Cocoa Flavanols Sleep Randomized Trial | The Mediterranean diet (MedDiet), rich in fruits, vegetables, whole grains, legumes, fish, and extra virgin olive oil, has been consistently associated with better cognitive outcomes and reduced risk of neurodegeneration. | 4 | Fekete M (2025) | Mediterranean Diet, Polyphenols, and Neuroprotection: Mechanistic Insights into Resveratrol and Oleuropein. |
| Cocoa Flavanols Sleep Randomized Trial | Aim: This narrative review summarizes current evidence on the role of the MedDiet in slowing the progression of neurodegenerative diseases, with a particular focus on polyphenols such as resveratrol and oleuropein as key bioactive mediators. | 4 | Fekete M (2025) | Mediterranean Diet, Polyphenols, and Neuroprotection: Mechanistic Insights into Resveratrol and Oleuropein. |
| Cocoa Flavanols Sleep Randomized Trial | Background: Neurodegenerative diseases, including Alzheimer's disease and Parkinson's disease, are among the leading causes of disability and mortality worldwide. | 4 | Fekete M (2025) | Mediterranean Diet, Polyphenols, and Neuroprotection: Mechanistic Insights into Resveratrol and Oleuropein. |
Source documents