evidence table
Citrus Bergamot Cholesterol Meta-Analysis Evidence Table
Structured evidence table for Citrus Bergamot Cholesterol Meta-Analysis, generated from 2 reusable source documents in the Migaku knowledge base.
| topic | claim | evidence level | citation | source |
|---|---|---|---|---|
| Citrus Bergamot Cholesterol Meta-Analysis | Epidemiological studies indicate that CRS affects a substantial proportion of patients, with an estimated prevalence of up to 0.4% in the general population and 2–3% in individuals with diabetes and heart failure, and is associated with increased morbidity and mortality [,]. | 3 | Carollo Caterina (2026) | Nature’s Bioactives in Cardiorenal Syndrome: Polyphenols at the Crossroads—Preclinical Insights into Redox, Inflammation, and Mitochondrial Protection |
| Citrus Bergamot Cholesterol Meta-Analysis | Most preclinical studies investigating polyphenolic interventions have focused on type IV and type V CRS, particularly diabetes-induced chronic kidney disease with associated cardiovascular dysfunction [,]. | 3 | Carollo Caterina (2026) | Nature’s Bioactives in Cardiorenal Syndrome: Polyphenols at the Crossroads—Preclinical Insights into Redox, Inflammation, and Mitochondrial Protection |
| Citrus Bergamot Cholesterol Meta-Analysis | Specifically, gut dysbiosis leads to an increased intestinal permeability (leaky gut), allowing the translocation of microbiota-derived uremic toxins (such as p-cresyl sulfate and TMAO) into the systemic circulation [,]. | 3 | Carollo Caterina (2026) | Nature’s Bioactives in Cardiorenal Syndrome: Polyphenols at the Crossroads—Preclinical Insights into Redox, Inflammation, and Mitochondrial Protection |
| Citrus Bergamot Cholesterol Meta-Analysis | 1 2 3 4 5 6 7 1 2 1 2 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 Figure 1 Cardiorenal syndromes (CRS) describe the complex bidirectional interaction between the heart and the kidneys, whereby acute or chronic dysfunction of one organ induces structural and functional impairment of the other []. | 3 | Carollo Caterina (2026) | Nature’s Bioactives in Cardiorenal Syndrome: Polyphenols at the Crossroads—Preclinical Insights into Redox, Inflammation, and Mitochondrial Protection |
| Citrus Bergamot Cholesterol Meta-Analysis | Cardiovascular disease (CVD) remains the leading cause of death worldwide, with elevated low-density lipoprotein cholesterol (LDL-C) as a major risk factor. | 3 | Jacobo-Velázquez DA (2025) | Functional Foods for Cholesterol Management: A Review of the Mechanisms, Efficacy, and a Novel Cholesterol-Lowering Capacity Index. |
| Citrus Bergamot Cholesterol Meta-Analysis | Building on these strategies, the CLCI is then proposed as a practical scoring system, analogous to the glycemic index for blood sugar, that integrates the evidence-based potency of ingredients, effective dosing, and synergistic interactions into a single metric. | 3 | Jacobo-Velázquez DA (2025) | Functional Foods for Cholesterol Management: A Review of the Mechanisms, Efficacy, and a Novel Cholesterol-Lowering Capacity Index. |
| Citrus Bergamot Cholesterol Meta-Analysis | Beyond medications, dietary interventions and functional foods offer significant cholesterol-lowering potential. | 3 | Jacobo-Velázquez DA (2025) | Functional Foods for Cholesterol Management: A Review of the Mechanisms, Efficacy, and a Novel Cholesterol-Lowering Capacity Index. |
Source documents