topicCitrulline Endurance Randomized Trial
claimThis involves addressing the effects of high‐intensity exercise, including increased glycolysis, blood lactate accumulation, fatigue, muscle soreness, local inflammation, and oxidative stress (MacIntyre et al. ; Mutch and Banister ; Zerba et al. ).
evidence level2
citationNorouzzadeh Mostafa (2025)
sourceThe Effects of Watermelon Juice on Muscle Hypertrophy, Exercise Performance, and Muscle Soreness in Non‐Athlete Men Undergoing Endurance Training: A Randomized Controlled Trial
topicCitrulline Endurance Randomized Trial
claimStudies have indicated that supplementation with watermelon juice before exercise in male runners resulted in improved exercise strength, reduced perceived exertion and muscle soreness after exercise, and decreased plasma lactate concentrations in resistance‐trained males (Martínez‐Sánchez, Alacid, et al. ; Martínez‐Sánchez, Ramos‐Campo, et al. ).
evidence level2
citationNorouzzadeh Mostafa (2025)
sourceThe Effects of Watermelon Juice on Muscle Hypertrophy, Exercise Performance, and Muscle Soreness in Non‐Athlete Men Undergoing Endurance Training: A Randomized Controlled Trial
topicCitrulline Endurance Randomized Trial
claimshowed that acute watermelon juice (1.2 g of L‐citrulline) or enriched watermelon juice (6 g L‐citrulline) supplementation reduced muscle soreness but did not improve performance in untrained individuals (Tarazona‐Díaz et al. ).
evidence level2
citationNorouzzadeh Mostafa (2025)
sourceThe Effects of Watermelon Juice on Muscle Hypertrophy, Exercise Performance, and Muscle Soreness in Non‐Athlete Men Undergoing Endurance Training: A Randomized Controlled Trial
topicCitrulline Endurance Randomized Trial
claim2016 1996 1983 1990 1991 2006 2002 Scientists are working towards developing a highly effective method to optimize exercise performance (Yan et al. ).
evidence level2
citationNorouzzadeh Mostafa (2025)
sourceThe Effects of Watermelon Juice on Muscle Hypertrophy, Exercise Performance, and Muscle Soreness in Non‐Athlete Men Undergoing Endurance Training: A Randomized Controlled Trial
topicCitrulline Endurance Randomized Trial
claimThrough its involvement in NO-related pathways, L-ARG supplementation has been associated with changes in vascular function and blood flow, which may influence exercise-related physiological responses (,–).
evidence level4
citationUçar Halil (2026)
sourceAcute effects of citrulline malate and L-arginine, alone and in combination, on anaerobic performance indicators in highly trained taekwondo athletes
topicCitrulline Endurance Randomized Trial
claimHowever, the findings across these studies remain inconsistent, and conclusive evidence supporting clear performance or recovery benefits has yet to be established.
evidence level4
citationUçar Halil (2026)
sourceAcute effects of citrulline malate and L-arginine, alone and in combination, on anaerobic performance indicators in highly trained taekwondo athletes
topicCitrulline Endurance Randomized Trial
claimNo significant sequence effect was detected (= 1.08,= 0.393, ηp= 0.213), and no significant period × sequence interaction was observed (= 1.04,= 0.430, ηp= 0.206), indicating no statistically significant evidence of meaningful carryover effects and supporting the adequacy of the 72-h washout period.
evidence level4
citationUçar Halil (2026)
sourceAcute effects of citrulline malate and L-arginine, alone and in combination, on anaerobic performance indicators in highly trained taekwondo athletes
topicCitrulline Endurance Randomized Trial
claim1 2 3 Taekwondo is a full-contact martial art in which successful performance is largely determined by the execution of high-force kicking techniques directed to the trunk protector or head of the opponent (,).
evidence level4
citationUçar Halil (2026)
sourceAcute effects of citrulline malate and L-arginine, alone and in combination, on anaerobic performance indicators in highly trained taekwondo athletes