evidence table

Cissus Joint Stiffness Randomized Trial Evidence Table

Structured evidence table for Cissus Joint Stiffness Randomized Trial, generated from 2 reusable source documents in the Migaku knowledge base.

topicclaimevidence levelcitationsource
Cissus Joint Stiffness Randomized TrialLong-term use of nonsteroidal anti-inflammatory drugs increases the risk of gastrointestinal bleeding and cardiovascular complications,while intra-articular corticosteroid injections, although effective for short-term pain management, can accelerate cartilage degeneration.To date, there are no approved medications that reverse or halt the progression of osteoarthritis.3Yuan Shuai (2026)Greening Bone Healing: The Emerging Role of Plant-Derived Exosome-Like Nanoparticles in Osteoporosis and Osteoarthritis Therapy
Cissus Joint Stiffness Randomized TrialWith advances in separation and purification methods, researchers are now able to efficiently extract functional exosomes from diverse plant tissues, such as roots, stems, leaves, fruits, and seeds.There is increasing evidence that PDENs possess remarkable potential for regulating host cell functions and participating in disease prevention and therapy.3Yuan Shuai (2026)Greening Bone Healing: The Emerging Role of Plant-Derived Exosome-Like Nanoparticles in Osteoporosis and Osteoarthritis Therapy
Cissus Joint Stiffness Randomized TrialWe then discuss how PDENs and related EVs modulate bone and joint homeostasis, with a focus on preclinical evidence in osteoporosis and osteoarthritis models.3Yuan Shuai (2026)Greening Bone Healing: The Emerging Role of Plant-Derived Exosome-Like Nanoparticles in Osteoporosis and Osteoarthritis Therapy
Cissus Joint Stiffness Randomized TrialWhile joint replacement surgery remains the final option for advanced cases, its widespread adoption is restricted by surgical complications and the limited lifespan of prostheses.Consequently, there is an urgent need to develop novel biological treatment strategies for osteoarthritis that are both efficacious and safe, and exosomes have emerged as promising therapeutic candidates.3Yuan Shuai (2026)Greening Bone Healing: The Emerging Role of Plant-Derived Exosome-Like Nanoparticles in Osteoporosis and Osteoarthritis Therapy
Cissus Joint Stiffness Randomized TrialConclusion Asthiposhak Tablets exhibited significant efficacy in enhancing both BMD (T-score) and Ayurvedic Symptom Score, thereby substantiating their osteoprotective potential in individuals with Asthikshaya (osteopenia).4Kumar K (2023)A Pilot, Open-Label, Proof-of-Concept Study To Evaluate the Efficacy and Safety of Asthiposhak® Tablets in Participants Suffering From Asthikshaya or Osteopenia.
Cissus Joint Stiffness Randomized TrialFurthermore, the tablets were found to reduce the levels of biochemical markers, such as serum bone-specific alkaline phosphatase and osteocalcin, suggesting their anti-resorptive action.4Kumar K (2023)A Pilot, Open-Label, Proof-of-Concept Study To Evaluate the Efficacy and Safety of Asthiposhak® Tablets in Participants Suffering From Asthikshaya or Osteopenia.
Cissus Joint Stiffness Randomized TrialIntroduction Both osteoporosis and osteopenia are prevalent public health concerns worldwide and can lead to debilitating bone fractures.4Kumar K (2023)A Pilot, Open-Label, Proof-of-Concept Study To Evaluate the Efficacy and Safety of Asthiposhak® Tablets in Participants Suffering From Asthikshaya or Osteopenia.
Cissus Joint Stiffness Randomized TrialThis study aimed to assess the efficacy of Asthiposhak® Tablets in individuals with Asthikshaya (osteopenia) by measuring changes in the bone mineral density (BMD) score before and after the intervention, specifically between visit 1 (baseline) and visit 8 (after 180 days of treatment).4Kumar K (2023)A Pilot, Open-Label, Proof-of-Concept Study To Evaluate the Efficacy and Safety of Asthiposhak® Tablets in Participants Suffering From Asthikshaya or Osteopenia.
topicCissus Joint Stiffness Randomized Trial
claimLong-term use of nonsteroidal anti-inflammatory drugs increases the risk of gastrointestinal bleeding and cardiovascular complications,while intra-articular corticosteroid injections, although effective for short-term pain management, can accelerate cartilage degeneration.To date, there are no approved medications that reverse or halt the progression of osteoarthritis.
evidence level3
citationYuan Shuai (2026)
sourceGreening Bone Healing: The Emerging Role of Plant-Derived Exosome-Like Nanoparticles in Osteoporosis and Osteoarthritis Therapy
topicCissus Joint Stiffness Randomized Trial
claimWith advances in separation and purification methods, researchers are now able to efficiently extract functional exosomes from diverse plant tissues, such as roots, stems, leaves, fruits, and seeds.There is increasing evidence that PDENs possess remarkable potential for regulating host cell functions and participating in disease prevention and therapy.
evidence level3
citationYuan Shuai (2026)
sourceGreening Bone Healing: The Emerging Role of Plant-Derived Exosome-Like Nanoparticles in Osteoporosis and Osteoarthritis Therapy
topicCissus Joint Stiffness Randomized Trial
claimWe then discuss how PDENs and related EVs modulate bone and joint homeostasis, with a focus on preclinical evidence in osteoporosis and osteoarthritis models.
evidence level3
citationYuan Shuai (2026)
sourceGreening Bone Healing: The Emerging Role of Plant-Derived Exosome-Like Nanoparticles in Osteoporosis and Osteoarthritis Therapy
topicCissus Joint Stiffness Randomized Trial
claimWhile joint replacement surgery remains the final option for advanced cases, its widespread adoption is restricted by surgical complications and the limited lifespan of prostheses.Consequently, there is an urgent need to develop novel biological treatment strategies for osteoarthritis that are both efficacious and safe, and exosomes have emerged as promising therapeutic candidates.
evidence level3
citationYuan Shuai (2026)
sourceGreening Bone Healing: The Emerging Role of Plant-Derived Exosome-Like Nanoparticles in Osteoporosis and Osteoarthritis Therapy
topicCissus Joint Stiffness Randomized Trial
claimConclusion Asthiposhak Tablets exhibited significant efficacy in enhancing both BMD (T-score) and Ayurvedic Symptom Score, thereby substantiating their osteoprotective potential in individuals with Asthikshaya (osteopenia).
evidence level4
citationKumar K (2023)
sourceA Pilot, Open-Label, Proof-of-Concept Study To Evaluate the Efficacy and Safety of Asthiposhak® Tablets in Participants Suffering From Asthikshaya or Osteopenia.
topicCissus Joint Stiffness Randomized Trial
claimFurthermore, the tablets were found to reduce the levels of biochemical markers, such as serum bone-specific alkaline phosphatase and osteocalcin, suggesting their anti-resorptive action.
evidence level4
citationKumar K (2023)
sourceA Pilot, Open-Label, Proof-of-Concept Study To Evaluate the Efficacy and Safety of Asthiposhak® Tablets in Participants Suffering From Asthikshaya or Osteopenia.
topicCissus Joint Stiffness Randomized Trial
claimIntroduction Both osteoporosis and osteopenia are prevalent public health concerns worldwide and can lead to debilitating bone fractures.
evidence level4
citationKumar K (2023)
sourceA Pilot, Open-Label, Proof-of-Concept Study To Evaluate the Efficacy and Safety of Asthiposhak® Tablets in Participants Suffering From Asthikshaya or Osteopenia.
topicCissus Joint Stiffness Randomized Trial
claimThis study aimed to assess the efficacy of Asthiposhak® Tablets in individuals with Asthikshaya (osteopenia) by measuring changes in the bone mineral density (BMD) score before and after the intervention, specifically between visit 1 (baseline) and visit 8 (after 180 days of treatment).
evidence level4
citationKumar K (2023)
sourceA Pilot, Open-Label, Proof-of-Concept Study To Evaluate the Efficacy and Safety of Asthiposhak® Tablets in Participants Suffering From Asthikshaya or Osteopenia.

Learn next

Related evidence and supplement guides

SupplementCollagen PeptidesHydrolysed collagen that stimulates fibroblasts — evidence for joints, skin elasticity, and tend...GuideCissus Joint Stiffness Randomized Trial: What the Evidence SaysCissus Joint Stiffness Randomized Trial has 2 source documents in the current Migaku evidence da...GuideHyaluronic Acid Joint Stiffness Randomized Trial: What the Evidence SaysHyaluronic Acid Joint Stiffness Randomized Trial has 2 source documents in the current Migaku ev...GuideCollagen Joint Pain Randomized Trial: What the Evidence SaysCollagen Joint Pain Randomized Trial has 3 source documents in the current Migaku evidence datab...GuideBoswellia Joint Comfort Randomized Trial: What the Evidence SaysBoswellia Joint Comfort Randomized Trial has 2 source documents in the current Migaku evidence d...AnswerDoes Collagen Joint Pain Randomized Trial work?Collagen Joint Pain Randomized Trial has evidence relevant to strength of evidence and what the...AnswerIs Collagen Joint Pain Randomized Trial safe?Collagen Joint Pain Randomized Trial has evidence relevant to safety, limits, and clinician-disc...AnswerWhat does the evidence say about Collagen Joint Pain Randomized Trial?Collagen Joint Pain Randomized Trial has evidence relevant to benefits, uncertainty, and practic...

Source documents

  1. Greening Bone Healing: The Emerging Role of Plant-Derived Exosome-Like Nanoparticles in Osteoporosis and Osteoarthritis Therapy
  2. A Pilot, Open-Label, Proof-of-Concept Study To Evaluate the Efficacy and Safety of Asthiposhak® Tablets in Participants Suffering From Asthikshaya or Osteopenia.