evidence table

Choline Sleep Quality Randomized Trial Evidence Table

Structured evidence table for Choline Sleep Quality Randomized Trial, generated from 2 reusable source documents in the Migaku knowledge base.

topicclaimevidence levelcitationsource
Choline Sleep Quality Randomized Trial1 2 3–6 7 8 9 10–12 13 14 Hyperlipidemia (HLP) refers to a systemic lipid metabolism abnormality characterized by elevated levels of total cholesterol (TC), triglycerides (TG), and/or low-density lipoprotein cholesterol (LDL-C), and/or reduced levels of high-density lipoprotein cholesterol (HDL-C) in the plasma due to various causes.2Xie Haihua (2026)Impact of infrared moxibustion for patients with mild hyperlipidemia: a protocol for a randomized controlled trial
Choline Sleep Quality Randomized TrialHLP, particularly elevated LDL-C levels, has been established as a risk factor for cardiovascular diseases and cognitive disorders (CD) [,].2Xie Haihua (2026)Impact of infrared moxibustion for patients with mild hyperlipidemia: a protocol for a randomized controlled trial
Choline Sleep Quality Randomized TrialIt has been reported that alterations in plasma lipid profiles appear to exacerbate cognitive decline, thereby increasing the risk of developing Alzheimer’s disease in non-demented elderly individuals [].2Xie Haihua (2026)Impact of infrared moxibustion for patients with mild hyperlipidemia: a protocol for a randomized controlled trial
Choline Sleep Quality Randomized TrialWhile intrinsic genetic factors drive much of this neurodevelopment, emerging evidence highlights the influence of extrinsic factors, particularly gut health, sleep architecture, and nutrition [,].3Chaturvedi Devyani (2026)Interconnected Developmental Trajectories of the Brain, Gut, and Sleep in Early Life: The First 1000 Days of Nutritional Opportunity
Choline Sleep Quality Randomized TrialHowever, disruptions in this process may result from factors such as cesarean delivery, antibiotic exposure, early-life stress, or diets lacking key nutrients and probiotics that favorably modulate the gut microbiota, thereby directly impacting neurodevelopmental outcomes.3Chaturvedi Devyani (2026)Interconnected Developmental Trajectories of the Brain, Gut, and Sleep in Early Life: The First 1000 Days of Nutritional Opportunity
Choline Sleep Quality Randomized TrialThe gut microbial community and the developing brain evolve in parallel, with increasing evidence suggesting a bidirectional relationship that influences emotional regulation and cognitive function [].3Chaturvedi Devyani (2026)Interconnected Developmental Trajectories of the Brain, Gut, and Sleep in Early Life: The First 1000 Days of Nutritional Opportunity
Choline Sleep Quality Randomized Trial1 2 3 4 5 6 7 8 9 The adult brain is a complex structure with more than 100 billion neurons [].3Chaturvedi Devyani (2026)Interconnected Developmental Trajectories of the Brain, Gut, and Sleep in Early Life: The First 1000 Days of Nutritional Opportunity
topicCholine Sleep Quality Randomized Trial
claim1 2 3–6 7 8 9 10–12 13 14 Hyperlipidemia (HLP) refers to a systemic lipid metabolism abnormality characterized by elevated levels of total cholesterol (TC), triglycerides (TG), and/or low-density lipoprotein cholesterol (LDL-C), and/or reduced levels of high-density lipoprotein cholesterol (HDL-C) in the plasma due to various causes.
evidence level2
citationXie Haihua (2026)
sourceImpact of infrared moxibustion for patients with mild hyperlipidemia: a protocol for a randomized controlled trial
topicCholine Sleep Quality Randomized Trial
claimHLP, particularly elevated LDL-C levels, has been established as a risk factor for cardiovascular diseases and cognitive disorders (CD) [,].
evidence level2
citationXie Haihua (2026)
sourceImpact of infrared moxibustion for patients with mild hyperlipidemia: a protocol for a randomized controlled trial
topicCholine Sleep Quality Randomized Trial
claimIt has been reported that alterations in plasma lipid profiles appear to exacerbate cognitive decline, thereby increasing the risk of developing Alzheimer’s disease in non-demented elderly individuals [].
evidence level2
citationXie Haihua (2026)
sourceImpact of infrared moxibustion for patients with mild hyperlipidemia: a protocol for a randomized controlled trial
topicCholine Sleep Quality Randomized Trial
claimWhile intrinsic genetic factors drive much of this neurodevelopment, emerging evidence highlights the influence of extrinsic factors, particularly gut health, sleep architecture, and nutrition [,].
evidence level3
citationChaturvedi Devyani (2026)
sourceInterconnected Developmental Trajectories of the Brain, Gut, and Sleep in Early Life: The First 1000 Days of Nutritional Opportunity
topicCholine Sleep Quality Randomized Trial
claimHowever, disruptions in this process may result from factors such as cesarean delivery, antibiotic exposure, early-life stress, or diets lacking key nutrients and probiotics that favorably modulate the gut microbiota, thereby directly impacting neurodevelopmental outcomes.
evidence level3
citationChaturvedi Devyani (2026)
sourceInterconnected Developmental Trajectories of the Brain, Gut, and Sleep in Early Life: The First 1000 Days of Nutritional Opportunity
topicCholine Sleep Quality Randomized Trial
claimThe gut microbial community and the developing brain evolve in parallel, with increasing evidence suggesting a bidirectional relationship that influences emotional regulation and cognitive function [].
evidence level3
citationChaturvedi Devyani (2026)
sourceInterconnected Developmental Trajectories of the Brain, Gut, and Sleep in Early Life: The First 1000 Days of Nutritional Opportunity
topicCholine Sleep Quality Randomized Trial
claim1 2 3 4 5 6 7 8 9 The adult brain is a complex structure with more than 100 billion neurons [].
evidence level3
citationChaturvedi Devyani (2026)
sourceInterconnected Developmental Trajectories of the Brain, Gut, and Sleep in Early Life: The First 1000 Days of Nutritional Opportunity

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Source documents

  1. Impact of infrared moxibustion for patients with mild hyperlipidemia: a protocol for a randomized controlled trial
  2. Interconnected Developmental Trajectories of the Brain, Gut, and Sleep in Early Life: The First 1000 Days of Nutritional Opportunity