topicCholine Mood Randomized Trial
claimThis review synthesizes current evidence on the effects of both plant- and animal-derived foods on cognitive outcomes from early development through older adulthood.
evidence level4
citationHardaway C (2026)
sourceBrain Foods: A Narrative Review of Food Items and Their Impact on Cognition over the Life Course.
topicCholine Mood Randomized Trial
claimEvidence was evaluated across life stages, considering nutrient bioavailability, dietary patterns, and the interplay between structural, socioeconomic, and environmental factors that influence access to these foods.
evidence level4
citationHardaway C (2026)
sourceBrain Foods: A Narrative Review of Food Items and Their Impact on Cognition over the Life Course.
topicCholine Mood Randomized Trial
claimIn early childhood, eggs, meat, and nuts were linked to improved neurodevelopment and reductions in developmental delays, while evidence for seafood and dairy was more mixed.
evidence level4
citationHardaway C (2026)
sourceBrain Foods: A Narrative Review of Food Items and Their Impact on Cognition over the Life Course.
topicCholine Mood Randomized Trial
claimBackground/Objectives : Cognitive function is fundamental to daily life, and nutrition is a key modifiable determinant of brain health across the lifespan.
evidence level4
citationHardaway C (2026)
sourceBrain Foods: A Narrative Review of Food Items and Their Impact on Cognition over the Life Course.
topicCholine Mood Randomized Trial
claimAlthough L-α-GPC has been discussed in both neurodegenerative and vascular-related cognitive disorders, the available evidence remains heterogeneous.
evidence level4
citationPutri Vannisa Artasya (2026)
sourceL-α-GPC in Cognitive Decline: Mechanisms and Clinical Evidence in Neurodegenerative Disorders
topicCholine Mood Randomized Trial
claimTherefore, a careful and contextualized interpretation of the literature is necessary, particularly when comparing evidence across Alzheimer’s disease, Parkinson’s disease-related cognitive decline, and cognitive impairment associated with cerebrovascular conditions.
evidence level4
citationPutri Vannisa Artasya (2026)
sourceL-α-GPC in Cognitive Decline: Mechanisms and Clinical Evidence in Neurodegenerative Disorders
topicCholine Mood Randomized Trial
claimGiven this background, the present narrative review focuses primarily on the mechanistic and clinical evidence regarding L-α-GPC in cognitive decline associated with neurodegenerative disorders, while also acknowledging relevant findings from studies of vascular- or cerebrovascular-related cognitive impairment where appropriate.
evidence level4
citationPutri Vannisa Artasya (2026)
sourceL-α-GPC in Cognitive Decline: Mechanisms and Clinical Evidence in Neurodegenerative Disorders
topicCholine Mood Randomized Trial
claim1 2 Neurodegeneration involves the progressive loss of neuronal structure and function, leading to cognitive and motor impairments.
evidence level4
citationPutri Vannisa Artasya (2026)
sourceL-α-GPC in Cognitive Decline: Mechanisms and Clinical Evidence in Neurodegenerative Disorders