Structured evidence table for Carnosine Sleep Randomized Trial, generated from 2 reusable source documents in the Migaku knowledge base.
| topic | claim | evidence level | citation | source |
|---|---|---|---|---|
| Carnosine Sleep Randomized Trial | Mental fatigue is a psychobiological state caused by prolonged periods of demanding cognitive activity that affects many aspects of daily life. | 2 | Shimomasuda M (2026) | Effects of a single dose of L-histidine on mental fatigue and vigor in participants with high fatigue levels: a randomized controlled trial. |
| Carnosine Sleep Randomized Trial | Two weeks of L-histidine daily ingestion in humans significantly improves mood states compared with a placebo; however, the effects of a single dose are unknown. | 2 | Shimomasuda M (2026) | Effects of a single dose of L-histidine on mental fatigue and vigor in participants with high fatigue levels: a randomized controlled trial. |
| Carnosine Sleep Randomized Trial | Individuals with T2DM have a higher risk of mental health disorders (Arias et al. ; Deshpande et al. ; Ducat et al. ), with the prevalence of depression reported to be two‐fold higher in those with T2DM compared with the general population (Roy and Lloyd ). | 2 | Kabthymer Robel Hussen (2026) | The Effect of Carnosine Supplementation on Depressive Symptoms and Health‐Related Quality of Life in Individuals With Prediabetes and Well‐Controlled Type 2 Diabetes: A Randomized Controlled Trial |
| Carnosine Sleep Randomized Trial | Similarly, the prevalence of depression is moderately increased in individuals with prediabetes compared with their normo‐glycaemic counterparts (Chen et al. ). | 2 | Kabthymer Robel Hussen (2026) | The Effect of Carnosine Supplementation on Depressive Symptoms and Health‐Related Quality of Life in Individuals With Prediabetes and Well‐Controlled Type 2 Diabetes: A Randomized Controlled Trial |
| Carnosine Sleep Randomized Trial | This increased risk may be partly due to diabetes‐related distress, which affects a large proportion of this population and can contribute to depressive symptoms (Perrin et al. ). | 2 | Kabthymer Robel Hussen (2026) | The Effect of Carnosine Supplementation on Depressive Symptoms and Health‐Related Quality of Life in Individuals With Prediabetes and Well‐Controlled Type 2 Diabetes: A Randomized Controlled Trial |
| Carnosine Sleep Randomized Trial | 2021 2023 2019 2023 2022 Globally, approximately half a billion individuals live with diabetes, with type 2 diabetes mellitus (T2DM) accounting for 90% of the disease burden (IDF ). | 2 | Kabthymer Robel Hussen (2026) | The Effect of Carnosine Supplementation on Depressive Symptoms and Health‐Related Quality of Life in Individuals With Prediabetes and Well‐Controlled Type 2 Diabetes: A Randomized Controlled Trial |
Source documents