topicCalcium Muscle Function Randomized Trial
claimThe authors suggested that defective energy-transduction mechanisms may play a key role in initiating the atrophic process and speculated that reduced ATP supply from aerobic metabolism could limit protein biosynthesis in denervated muscle [,].
evidence level3
citationSharlo Kristina A. (2026)
sourceMitochondrial Impairment in Unloaded Postural Muscle: Mechanisms Driving Loss of Muscle Function and Mass
topicCalcium Muscle Function Randomized Trial
claimMechanisms associated with mitochondria-related induction of inactivity-induced muscle atrophy include the generation of ROS, disturbances in mitochondrial dynamics (fission and fusion), decreased mitochondrial biogenesis, impaired regulation of autophagy, and apoptosis [].
evidence level3
citationSharlo Kristina A. (2026)
sourceMitochondrial Impairment in Unloaded Postural Muscle: Mechanisms Driving Loss of Muscle Function and Mass
topicCalcium Muscle Function Randomized Trial
claimGiven that subsarcolemmal mitochondria exhibit both a higher rate of ROS production and a greater sensitivity to oxidative stress, it can be hypothesized that this reduction is associated with accelerated ROS-induced damage to this subpopulation, followed by mitophagy.
evidence level3
citationSharlo Kristina A. (2026)
sourceMitochondrial Impairment in Unloaded Postural Muscle: Mechanisms Driving Loss of Muscle Function and Mass
topicCalcium Muscle Function Randomized Trial
claim1 2 3 4 5 6 7 8 9 9 9 10 The significance of skeletal muscles cannot be overstated.
evidence level3
citationSharlo Kristina A. (2026)
sourceMitochondrial Impairment in Unloaded Postural Muscle: Mechanisms Driving Loss of Muscle Function and Mass
topicCalcium Muscle Function Randomized Trial
claimAsthma is a heterogeneous disease that varies in clinical presentation, severity, and underlying biology but consistently involves airway remodeling (AR) and airway hyperresponsiveness (AHR), which is characterized by excessive airway narrowing in response to various stimuli.
evidence level4
citationRoy S (2026)
sourceIntegrating GPCR Regulation and Calcium Dynamics in Airway Smooth Muscle Function: A Comprehensive Review.
topicCalcium Muscle Function Randomized Trial
claimAirway smooth muscle (ASM) cells are primary contributors to airway hyperresponsiveness and bronchoconstriction.
evidence level4
citationRoy S (2026)
sourceIntegrating GPCR Regulation and Calcium Dynamics in Airway Smooth Muscle Function: A Comprehensive Review.