Structured evidence table for Calcium Fracture Prevention Meta-Analysis, generated from 2 reusable source documents in the Migaku knowledge base.
| topic | claim | evidence level | citation | source |
|---|---|---|---|---|
| Calcium Fracture Prevention Meta-Analysis | Secondary outcomes included the risk of hip fracture, non-vertebral fracture, vertebral fracture, and falling, as well as the total number of falls. | 1 | Massé O (2026) | Calcium, vitamin D, or combined supplementation to prevent fractures and falls: systematic review and meta-analysis. |
| Calcium Fracture Prevention Meta-Analysis | Pairs of reviewers independently screened trials, extracted data, and assessed risk of bias using the second version of Cochrane's risk of bias tool. | 1 | Massé O (2026) | Calcium, vitamin D, or combined supplementation to prevent fractures and falls: systematic review and meta-analysis. |
| Calcium Fracture Prevention Meta-Analysis | Participants in most of the trials were community dwelling (87%) and not at high risk of fractures or falls (73%). | 1 | Massé O (2026) | Calcium, vitamin D, or combined supplementation to prevent fractures and falls: systematic review and meta-analysis. |
| Calcium Fracture Prevention Meta-Analysis | Objective To assess the effect of calcium, vitamin D, or combined supplementation on fractures and falls in adults. | 1 | Massé O (2026) | Calcium, vitamin D, or combined supplementation to prevent fractures and falls: systematic review and meta-analysis. |
| Calcium Fracture Prevention Meta-Analysis | Supported by this biological plausibility and by observational studies demonstrating a robust inverse association between serum 25-hydroxyvitamin D (25(OH)D) levels and the risk of fractures and falls, the medical community has witnessed a global surge in vitamin D screening and empiric supplementation over the past two decades []. | 3 | Kong Sung Hye (2026) | Revisiting the Role of Vitamin D in Fracture Prevention in the Era of Mega-Trials |
| Calcium Fracture Prevention Meta-Analysis | Furthermore, updated systematic reviews and meta-analyses published in 2025 have reinforced the conclusion that vitamin D supplementation does not reduce fall risk among community-dwelling older adults, with some analyses even suggesting potential harm at higher doses [-]. | 3 | Kong Sung Hye (2026) | Revisiting the Role of Vitamin D in Fracture Prevention in the Era of Mega-Trials |
| Calcium Fracture Prevention Meta-Analysis | Most notably, the 2024 Endocrine Society Clinical Practice Guideline now recommends against empiric vitamin D supplementation in healthy adults younger than 75 years, signaling a decisive transition from universal screening toward a more targeted, risk-based approach []. | 3 | Kong Sung Hye (2026) | Revisiting the Role of Vitamin D in Fracture Prevention in the Era of Mega-Trials |
| Calcium Fracture Prevention Meta-Analysis | 1 2 3 Vitamin D, often termed the ‘sunshine hormone,’ has been a cornerstone of musculoskeletal preventive medicine for decades. | 3 | Kong Sung Hye (2026) | Revisiting the Role of Vitamin D in Fracture Prevention in the Era of Mega-Trials |
Source documents