topicCaffeine Sleep Quality Randomized Trial
claimThe 2018 International Olympic Committee (IOC) reported that caffeine is among the five nutritional supplements whose positive effects on athletic performance are supported by scientific evidence [].
evidence level2
citationBingol Diedhiou Azize (2026)
sourceComparative effects of caffeine and paraxanthine on rowing performance and sleep quality: a randomized crossover study
topicCaffeine Sleep Quality Randomized Trial
claim5 3 6 Caffeine is metabolized by the CYP1A2 enzyme, which is found in the liver and is responsible for approximately 95% of the cytochrome P450 family [].
evidence level2
citationBingol Diedhiou Azize (2026)
sourceComparative effects of caffeine and paraxanthine on rowing performance and sleep quality: a randomized crossover study
topicCaffeine Sleep Quality Randomized Trial
claimThese metabolic rates are important factors in determining both the level of benefit from the ergogenic effects of caffeine and the risk of exposure to potential side effects in athletes.
evidence level2
citationBingol Diedhiou Azize (2026)
sourceComparative effects of caffeine and paraxanthine on rowing performance and sleep quality: a randomized crossover study
topicCaffeine Sleep Quality Randomized Trial
claim1 2 3 4 Various nootropic nutritional supplements are preferred by athletes to improve their physical (exercise-related) and cognitive performance.
evidence level2
citationBingol Diedhiou Azize (2026)
sourceComparative effects of caffeine and paraxanthine on rowing performance and sleep quality: a randomized crossover study
topicCaffeine Sleep Quality Randomized Trial
claimTotal distance in the 5mSRT increased following MEL + CAF and PLA + CAF conditions compared with PLA + PLA.
evidence level4
citationMahdi N (2026)
sourceMelatonin, Caffeine, or Their Combination: Effects on Sleep, Performance, Perceived Exertion in a Placebo-Controlled Crossover Study.
topicCaffeine Sleep Quality Randomized Trial
claimMoreover, MEL + CAF reduced muscle damage and inflammation markers compared with PLA + PLA, MEL + PLA, and PLA + CAF conditions ( p Conclusions : The ingestion of nocturnal MEL and next-day CAF was associated with improvements in certain high-intensity exercise performance outcomes, along with changes in muscle damage and inflammation.
evidence level4
citationMahdi N (2026)
sourceMelatonin, Caffeine, or Their Combination: Effects on Sleep, Performance, Perceived Exertion in a Placebo-Controlled Crossover Study.
topicCaffeine Sleep Quality Randomized Trial
claimBackground/Objectives : Melatonin (MEL) promotes sleep and recovery, while caffeine (CAF) enhances alertness and performance.
evidence level4
citationMahdi N (2026)
sourceMelatonin, Caffeine, or Their Combination: Effects on Sleep, Performance, Perceived Exertion in a Placebo-Controlled Crossover Study.
topicCaffeine Sleep Quality Randomized Trial
claimDespite their common use among athletes, their potential interaction remains underexplored.
evidence level4
citationMahdi N (2026)
sourceMelatonin, Caffeine, or Their Combination: Effects on Sleep, Performance, Perceived Exertion in a Placebo-Controlled Crossover Study.