topicCacao Flavanols Mood Randomized Trial
claimIt includes increased interferons, tumor necrosis factor, bradykinin, serine proteases, and soluble thrombomodulin, and altered clot lysis times [,,,,], all of which contribute to microvascular and thrombotic disease [,].
evidence level2
citationMunguía Levy (2026)
sourceEffects of Cacao Flavonoids in Long COVID-19 Patients with Chronic Fatigue: FLALOC, a Placebo-Controlled Randomized Clinical Trial
topicCacao Flavanols Mood Randomized Trial
claimA myriad of causes can trigger fatigue, but its development has been strongly associated with post-viral phases of infection.
evidence level2
citationMunguía Levy (2026)
sourceEffects of Cacao Flavonoids in Long COVID-19 Patients with Chronic Fatigue: FLALOC, a Placebo-Controlled Randomized Clinical Trial
topicCacao Flavanols Mood Randomized Trial
claimLong COVID-associated fatigue has been causally linked to sustained inflammation and to endothelial and mitochondrial dysfunction.
evidence level2
citationMunguía Levy (2026)
sourceEffects of Cacao Flavonoids in Long COVID-19 Patients with Chronic Fatigue: FLALOC, a Placebo-Controlled Randomized Clinical Trial
topicCacao Flavanols Mood Randomized Trial
claim1 2 3 4 5 6 7 8 Coronavirus disease 2019 (COVID-19) is caused by the acute respiratory syndrome coronavirus 2 (SARS-CoV-2).
evidence level2
citationMunguía Levy (2026)
sourceEffects of Cacao Flavonoids in Long COVID-19 Patients with Chronic Fatigue: FLALOC, a Placebo-Controlled Randomized Clinical Trial