Structured evidence table for Cacao Flavanols Memory Meta-Analysis, generated from 2 reusable source documents in the Migaku knowledge base.
| topic | claim | evidence level | citation | source |
|---|---|---|---|---|
| Cacao Flavanols Memory Meta-Analysis | Polyphenols strengthen the intestinal barrier and reduce endotoxemia; cocoa bean shell extracts protected against oxysterol‐induced intestinal damage and improved gut microbiota composition in preclinical models (Alia et al. ). | 3 | Akif Adnan (2026) | Dietary Polyphenols in Non‐Communicable Chronic Diseases: Neuro–Enteric Mechanisms, Multi‐Omics Biomarkers and Translational Opportunities |
| Cacao Flavanols Memory Meta-Analysis | While many epidemiological studies correlate polyphenol‐rich diets (e.g., Mediterranean diet) with reduced NCCD risk, causality is uncertain due to confounding and measurement error. | 3 | Akif Adnan (2026) | Dietary Polyphenols in Non‐Communicable Chronic Diseases: Neuro–Enteric Mechanisms, Multi‐Omics Biomarkers and Translational Opportunities |
| Cacao Flavanols Memory Meta-Analysis | Controlled trials provide more robust evidence but vary widely in doses, formulations, populations and endpoints. | 3 | Akif Adnan (2026) | Dietary Polyphenols in Non‐Communicable Chronic Diseases: Neuro–Enteric Mechanisms, Multi‐Omics Biomarkers and Translational Opportunities |
| Cacao Flavanols Memory Meta-Analysis | AMP BBB CNS COMT COSMOS CRP (hs‐CRP) CSF EGCG ENB‐2 (ENB) ENS EVOO FMD GAD‐7 (GAD) GM‐CSF (GM) HDL HOMA‐IR (HOMA) IBS IL IR LDL LPS MCI MMSE NADPH NCCD (NCCDs) PHGG PHQ‐9 (PHQ) PSQI PWV RBANS RCT SCFA SD TNF (TNF‐α) 2024 Non‐communicable chronic diseases account for the majority of morbidity and mortality worldwide. | 3 | Akif Adnan (2026) | Dietary Polyphenols in Non‐Communicable Chronic Diseases: Neuro–Enteric Mechanisms, Multi‐Omics Biomarkers and Translational Opportunities |
| Cacao Flavanols Memory Meta-Analysis | Thus, this review aimed to provide an overview of the latest research results on the effects of cacao on the prevention of CVDs and on biomarkers associated with these mechanisms. | 3 | Lee YG (2026) | Cardiovascular Protective Effects and Mechanisms of Action of Cacao: A Comprehensive Review. |
| Cacao Flavanols Memory Meta-Analysis | Cacao, the primary raw material for chocolate and certain beverages, is widely cultivated in the Americas and Asia. | 3 | Lee YG (2026) | Cardiovascular Protective Effects and Mechanisms of Action of Cacao: A Comprehensive Review. |
| Cacao Flavanols Memory Meta-Analysis | Furthermore, various components of cacao, including phenolic compounds, have been shown to be effective in preventing numerous diseases. | 3 | Lee YG (2026) | Cardiovascular Protective Effects and Mechanisms of Action of Cacao: A Comprehensive Review. |
Source documents