topicBranched Chain Amino Acids Muscle Soreness Randomized Trial
claimEIMD symptoms include increased muscle soreness, pain and reduced range of motion and muscle function [].
evidence level1
citationMuacevic Alexander (2025)
sourceThe Effect of Oral Pure Branched-Chain Amino Acid Supplementation on Exercise Performance and Body Composition: A Systematic Review
topicBranched Chain Amino Acids Muscle Soreness Randomized Trial
claimAs BCAAs compete for the same carrier as tryptophan, increased blood levels of tryptophan are believed to decrease serotonin uptake in the brain and hence reduce central fatigue [,].
evidence level1
citationMuacevic Alexander (2025)
sourceThe Effect of Oral Pure Branched-Chain Amino Acid Supplementation on Exercise Performance and Body Composition: A Systematic Review
topicBranched Chain Amino Acids Muscle Soreness Randomized Trial
claimLeucine monotherapy has been studied, and findings indicate that leucine alone can stimulate an anabolic effect [], whereas there is no evidence for such an effect for isoleucine or valine [].
evidence level1
citationMuacevic Alexander (2025)
sourceThe Effect of Oral Pure Branched-Chain Amino Acid Supplementation on Exercise Performance and Body Composition: A Systematic Review
topicBranched Chain Amino Acids Muscle Soreness Randomized Trial
claimPrevalence of branched-chain amino acid (BCAA) supplements 1 2 2 3 4 5 7 Sports supplements are increasing in popularity as more people take them to improve performance [].
evidence level1
citationMuacevic Alexander (2025)
sourceThe Effect of Oral Pure Branched-Chain Amino Acid Supplementation on Exercise Performance and Body Composition: A Systematic Review
topicBranched Chain Amino Acids Muscle Soreness Randomized Trial
claimResults Essential amino acids and leucine showed the most consistent associations with increased MPS and, in older adults, improvements in strength/lean mass.
evidence level4
citationNoh KW (2025)
sourceEffects of Amino Acid Supplementation on Muscle protein metabolism and adaptation: a narrative review of effects on muscle mass, strength, and sex differences.
topicBranched Chain Amino Acids Muscle Soreness Randomized Trial
claimConclusion Amino acid supplementation can support muscle anabolism and, in selected contexts, strength and recovery, best viewed as an adjunct to resistance training with individualized dosing/timing.
evidence level4
citationNoh KW (2025)
sourceEffects of Amino Acid Supplementation on Muscle protein metabolism and adaptation: a narrative review of effects on muscle mass, strength, and sex differences.
topicBranched Chain Amino Acids Muscle Soreness Randomized Trial
claimPurpose To review the effects of amino acid supplementation including essential, branched-chain, and non-essential amino acids on muscle mass, strength, and adaptation, with a focus on sex-specific differences.
evidence level4
citationNoh KW (2025)
sourceEffects of Amino Acid Supplementation on Muscle protein metabolism and adaptation: a narrative review of effects on muscle mass, strength, and sex differences.
topicBranched Chain Amino Acids Muscle Soreness Randomized Trial
claimMethods PubMed, ScienceDirect, and Google Scholar databases were searched for clinical and nonclinical studies on the effects of supplementation in adults, published between 1990 and 2025.
evidence level4
citationNoh KW (2025)
sourceEffects of Amino Acid Supplementation on Muscle protein metabolism and adaptation: a narrative review of effects on muscle mass, strength, and sex differences.