topicBoswellia Joint Function Meta-Analysis
claimHowever, prolonged NSAID use is associated with various adverse effects, including gastrointestinal complications, cardiovascular disease, and potential renal and hepatic toxicity [,].
evidence level1
citationZhang Yuntong (2025)
sourceComparative Effectiveness of Nutritional Supplements in the Treatment of Knee Osteoarthritis: A Network Meta-Analysis
topicBoswellia Joint Function Meta-Analysis
claimAs a result, many patients with KOA seek alternative or non-pharmacological therapies to relieve pain and functional impairment [,].
evidence level1
citationZhang Yuntong (2025)
sourceComparative Effectiveness of Nutritional Supplements in the Treatment of Knee Osteoarthritis: A Network Meta-Analysis
topicBoswellia Joint Function Meta-Analysis
claimNevertheless, the available clinical evidence regarding the efficacy of these nutritional supplements in KOA primarily consists of studies comparing individual supplements to placebo, with a paucity of high-quality, head-to-head trials directly comparing different supplements.
evidence level1
citationZhang Yuntong (2025)
sourceComparative Effectiveness of Nutritional Supplements in the Treatment of Knee Osteoarthritis: A Network Meta-Analysis
topicBoswellia Joint Function Meta-Analysis
claim1 2 3 4 5 6 7 8 Knee osteoarthritis (KOA) is a degenerative joint disease characterized by cartilage degradation and synovial inflammation, which typically presents with joint stiffness, swelling, pain, and restricted mobility [].
evidence level1
citationZhang Yuntong (2025)
sourceComparative Effectiveness of Nutritional Supplements in the Treatment of Knee Osteoarthritis: A Network Meta-Analysis
topicBoswellia Joint Function Meta-Analysis
claimBetween 1990 and 2020, OA prevalence increased by over 100%, and the years lived with disability (YLDs) have also risen sharply, creating a substantial economic burden on patients and healthcare systems [].
evidence level3
citationPatel Milan (2026)
sourceNutritional Interventions in Osteoarthritis: Mechanisms, Clinical Evidence, and Translational Opportunities
topicBoswellia Joint Function Meta-Analysis
claimRisk factors such as age, obesity, prior joint injury, and genetics drive this alarming upward trend, especially obesity, as it accounts for a growing fraction of the OA burden worldwide.
evidence level3
citationPatel Milan (2026)
sourceNutritional Interventions in Osteoarthritis: Mechanisms, Clinical Evidence, and Translational Opportunities
topicBoswellia Joint Function Meta-Analysis
claimLong-term use of NSAIDs or corticosteroids carries gastrointestinal and cardiovascular risk and often fails to protect cartilage [].
evidence level3
citationPatel Milan (2026)
sourceNutritional Interventions in Osteoarthritis: Mechanisms, Clinical Evidence, and Translational Opportunities
topicBoswellia Joint Function Meta-Analysis
claim1 1 1 1 Osteoarthritis (OA) affects a growing and expansive portion of the population worldwide.
evidence level3
citationPatel Milan (2026)
sourceNutritional Interventions in Osteoarthritis: Mechanisms, Clinical Evidence, and Translational Opportunities