topicBlueberry Mood Randomized Trial
claimPolyphenols strengthen the intestinal barrier and reduce endotoxemia; cocoa bean shell extracts protected against oxysterol‐induced intestinal damage and improved gut microbiota composition in preclinical models (Alia et al. ).
evidence level3
citationAkif Adnan (2026)
sourceDietary Polyphenols in Non‐Communicable Chronic Diseases: Neuro–Enteric Mechanisms, Multi‐Omics Biomarkers and Translational Opportunities
topicBlueberry Mood Randomized Trial
claimWhile many epidemiological studies correlate polyphenol‐rich diets (e.g., Mediterranean diet) with reduced NCCD risk, causality is uncertain due to confounding and measurement error.
evidence level3
citationAkif Adnan (2026)
sourceDietary Polyphenols in Non‐Communicable Chronic Diseases: Neuro–Enteric Mechanisms, Multi‐Omics Biomarkers and Translational Opportunities
topicBlueberry Mood Randomized Trial
claimControlled trials provide more robust evidence but vary widely in doses, formulations, populations and endpoints.
evidence level3
citationAkif Adnan (2026)
sourceDietary Polyphenols in Non‐Communicable Chronic Diseases: Neuro–Enteric Mechanisms, Multi‐Omics Biomarkers and Translational Opportunities
topicBlueberry Mood Randomized Trial
claimAMP BBB CNS COMT COSMOS CRP (hs‐CRP) CSF EGCG ENB‐2 (ENB) ENS EVOO FMD GAD‐7 (GAD) GM‐CSF (GM) HDL HOMA‐IR (HOMA) IBS IL IR LDL LPS MCI MMSE NADPH NCCD (NCCDs) PHGG PHQ‐9 (PHQ) PSQI PWV RBANS RCT SCFA SD TNF (TNF‐α) 2024 Non‐communicable chronic diseases account for the majority of morbidity and mortality worldwide.
evidence level3
citationAkif Adnan (2026)
sourceDietary Polyphenols in Non‐Communicable Chronic Diseases: Neuro–Enteric Mechanisms, Multi‐Omics Biomarkers and Translational Opportunities
topicBlueberry Mood Randomized Trial
claimThis review synthesizes current evidence on the effects of both plant- and animal-derived foods on cognitive outcomes from early development through older adulthood.
evidence level4
citationHardaway C (2026)
sourceBrain Foods: A Narrative Review of Food Items and Their Impact on Cognition over the Life Course.
topicBlueberry Mood Randomized Trial
claimEvidence was evaluated across life stages, considering nutrient bioavailability, dietary patterns, and the interplay between structural, socioeconomic, and environmental factors that influence access to these foods.
evidence level4
citationHardaway C (2026)
sourceBrain Foods: A Narrative Review of Food Items and Their Impact on Cognition over the Life Course.
topicBlueberry Mood Randomized Trial
claimIn early childhood, eggs, meat, and nuts were linked to improved neurodevelopment and reductions in developmental delays, while evidence for seafood and dairy was more mixed.
evidence level4
citationHardaway C (2026)
sourceBrain Foods: A Narrative Review of Food Items and Their Impact on Cognition over the Life Course.
topicBlueberry Mood Randomized Trial
claimBackground/Objectives : Cognitive function is fundamental to daily life, and nutrition is a key modifiable determinant of brain health across the lifespan.
evidence level4
citationHardaway C (2026)
sourceBrain Foods: A Narrative Review of Food Items and Their Impact on Cognition over the Life Course.