evidence table

Black Seed Sleep Randomized Trial Evidence Table

Structured evidence table for Black Seed Sleep Randomized Trial, generated from 2 reusable source documents in the Migaku knowledge base.

topicclaimevidence levelcitationsource
Black Seed Sleep Randomized TrialResults After 4 weeks of treatment, the VAS score, TCM syndrome score, PSQI score, levels of MCP-1, IL-6, TNF-α, CD8+, 5-HT, and SP in both groups significantly decreased compared to pre-treatment levels ( P P P P P Conclusion Acupuncture point paste therapy for PHN of the qi stagnation and blood stasis type has been shown to decrease levels of MCP-1, IL-6, TNF-α, CD8+, 5-HT, and SP in the blood.2Zhu S (2026)A randomized controlled trial of acupoint application for postherpetic neuralgia.
Black Seed Sleep Randomized TrialObjective To assess the clinical efficacy of acupressure application in treating postherpetic neuralgia (PHN) of the qi (vital energy) stagnation and blood stasis type, as well as its impact on blood inflammatory factors, T-cell subpopulations, and neurotransmitter levels.2Zhu S (2026)A randomized controlled trial of acupoint application for postherpetic neuralgia.
Black Seed Sleep Randomized TrialMethods A total of 134 patients diagnosed with PHN characterized by qi stagnation and blood stasis were randomly assigned to either the treatment group (67 patients, including 10 dropouts) or the control group (67 patients, including 7 dropouts).2Zhu S (2026)A randomized controlled trial of acupoint application for postherpetic neuralgia.
Black Seed Sleep Randomized TrialSeverity, frequency and duration of migraine attacks, headache daily result (HDR), quality of life, migraine disability, mental health, anthropometric indices, blood pressure, and serum levels of calcitonin gene-related peptide (CGRP), vascular cell adhesion molecules-1, total antioxidant capacity, and malondialdehyde were measured at baseline and end of the trial.2Eshaghian N (2025)Effects of grape seed extract supplementation on inflammatory biomarkers, oxidative stress, clinical symptoms, and quality of life in patients with migraine: A double-blinded randomized placebo-controlled clinical trial.
Black Seed Sleep Randomized TrialConclusion This study provides evidence supporting the beneficial effects of GSE supplement on the serum levels of CGRP.2Eshaghian N (2025)Effects of grape seed extract supplementation on inflammatory biomarkers, oxidative stress, clinical symptoms, and quality of life in patients with migraine: A double-blinded randomized placebo-controlled clinical trial.
Black Seed Sleep Randomized TrialBackground The current study was conducted to assess the effect of grape seed extract (GSE) supplementation on inflammatory biomarkers, oxidative stress, clinical symptoms, and quality of life in migraine patients.2Eshaghian N (2025)Effects of grape seed extract supplementation on inflammatory biomarkers, oxidative stress, clinical symptoms, and quality of life in patients with migraine: A double-blinded randomized placebo-controlled clinical trial.
Black Seed Sleep Randomized TrialMaterials and methods In this randomized double-blinded controlled clinical trial, 50 patients with migraine were randomly allocated to receive either 200 mg/day GSE supplement ( n = 25) or placebo ( n = 25) for 8 weeks.2Eshaghian N (2025)Effects of grape seed extract supplementation on inflammatory biomarkers, oxidative stress, clinical symptoms, and quality of life in patients with migraine: A double-blinded randomized placebo-controlled clinical trial.
topicBlack Seed Sleep Randomized Trial
claimResults After 4 weeks of treatment, the VAS score, TCM syndrome score, PSQI score, levels of MCP-1, IL-6, TNF-α, CD8+, 5-HT, and SP in both groups significantly decreased compared to pre-treatment levels ( P P P P P Conclusion Acupuncture point paste therapy for PHN of the qi stagnation and blood stasis type has been shown to decrease levels of MCP-1, IL-6, TNF-α, CD8+, 5-HT, and SP in the blood.
evidence level2
citationZhu S (2026)
sourceA randomized controlled trial of acupoint application for postherpetic neuralgia.
topicBlack Seed Sleep Randomized Trial
claimObjective To assess the clinical efficacy of acupressure application in treating postherpetic neuralgia (PHN) of the qi (vital energy) stagnation and blood stasis type, as well as its impact on blood inflammatory factors, T-cell subpopulations, and neurotransmitter levels.
evidence level2
citationZhu S (2026)
sourceA randomized controlled trial of acupoint application for postherpetic neuralgia.
topicBlack Seed Sleep Randomized Trial
claimMethods A total of 134 patients diagnosed with PHN characterized by qi stagnation and blood stasis were randomly assigned to either the treatment group (67 patients, including 10 dropouts) or the control group (67 patients, including 7 dropouts).
evidence level2
citationZhu S (2026)
sourceA randomized controlled trial of acupoint application for postherpetic neuralgia.
topicBlack Seed Sleep Randomized Trial
claimSeverity, frequency and duration of migraine attacks, headache daily result (HDR), quality of life, migraine disability, mental health, anthropometric indices, blood pressure, and serum levels of calcitonin gene-related peptide (CGRP), vascular cell adhesion molecules-1, total antioxidant capacity, and malondialdehyde were measured at baseline and end of the trial.
evidence level2
citationEshaghian N (2025)
sourceEffects of grape seed extract supplementation on inflammatory biomarkers, oxidative stress, clinical symptoms, and quality of life in patients with migraine: A double-blinded randomized placebo-controlled clinical trial.
topicBlack Seed Sleep Randomized Trial
claimConclusion This study provides evidence supporting the beneficial effects of GSE supplement on the serum levels of CGRP.
evidence level2
citationEshaghian N (2025)
sourceEffects of grape seed extract supplementation on inflammatory biomarkers, oxidative stress, clinical symptoms, and quality of life in patients with migraine: A double-blinded randomized placebo-controlled clinical trial.
topicBlack Seed Sleep Randomized Trial
claimBackground The current study was conducted to assess the effect of grape seed extract (GSE) supplementation on inflammatory biomarkers, oxidative stress, clinical symptoms, and quality of life in migraine patients.
evidence level2
citationEshaghian N (2025)
sourceEffects of grape seed extract supplementation on inflammatory biomarkers, oxidative stress, clinical symptoms, and quality of life in patients with migraine: A double-blinded randomized placebo-controlled clinical trial.
topicBlack Seed Sleep Randomized Trial
claimMaterials and methods In this randomized double-blinded controlled clinical trial, 50 patients with migraine were randomly allocated to receive either 200 mg/day GSE supplement ( n = 25) or placebo ( n = 25) for 8 weeks.
evidence level2
citationEshaghian N (2025)
sourceEffects of grape seed extract supplementation on inflammatory biomarkers, oxidative stress, clinical symptoms, and quality of life in patients with migraine: A double-blinded randomized placebo-controlled clinical trial.

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Source documents

  1. A randomized controlled trial of acupoint application for postherpetic neuralgia.
  2. Effects of grape seed extract supplementation on inflammatory biomarkers, oxidative stress, clinical symptoms, and quality of life in patients with migraine: A double-blinded randomized placebo-controlled clinical trial.