topicBlack Seed Oil Immune Meta-Analysis
claimAdditionally, the risk of disease development is significantly increased by comorbidities such as obesity, type 2 diabetes, and metabolic syndrome [].
evidence level3
citationFic Weronika (2026)
sourceThymoquinone in Atherosclerosis: A Multi-Target Nutraceutical Modulating Inflammation, Oxidative Stress, and Lipid Metabolism
topicBlack Seed Oil Immune Meta-Analysis
claimExcessive enlargement of the necrotic core relative to the thickness of the fibrous cap increases the risk of plaque rupture and thrombus formation [].
evidence level3
citationFic Weronika (2026)
sourceThymoquinone in Atherosclerosis: A Multi-Target Nutraceutical Modulating Inflammation, Oxidative Stress, and Lipid Metabolism
topicBlack Seed Oil Immune Meta-Analysis
claimThis study was conducted as a narrative review, the aim of which was to critically analyze the available scientific evidence regarding the role of TQ in modulating processes associated with atherosclerosis development, with a particular focus on inflammation, oxidative stress, and lipid metabolism disorders.
evidence level3
citationFic Weronika (2026)
sourceThymoquinone in Atherosclerosis: A Multi-Target Nutraceutical Modulating Inflammation, Oxidative Stress, and Lipid Metabolism
topicBlack Seed Oil Immune Meta-Analysis
claim1 2 3 2 3 4 5 5 6 2 In recent years, a significant increase in the prevalence of chronic cardiovascular diseases (CVD) has been reported in both developed and developing countries.
evidence level3
citationFic Weronika (2026)
sourceThymoquinone in Atherosclerosis: A Multi-Target Nutraceutical Modulating Inflammation, Oxidative Stress, and Lipid Metabolism
topicBlack Seed Oil Immune Meta-Analysis
claimPreclinical evidence suggests that CBD modulates endocannabinoid and serotonergic signaling, potentially contributing to the regulation of physiological processes associated with hyperarousal.
evidence level4
citationKovitkanit P (2026)
sourceMechanistic Pathways Linking Cannabidiol, Hemp Seed Oil and Black Sesame Oil in Hyperarousal Insomnia: A Narrative Review.
topicBlack Seed Oil Immune Meta-Analysis
claimHowever, the current evidence base is predominantly preclinical, and definitive conclusions regarding therapeutic efficacy or optimal dosing in humans remain limited.
evidence level4
citationKovitkanit P (2026)
sourceMechanistic Pathways Linking Cannabidiol, Hemp Seed Oil and Black Sesame Oil in Hyperarousal Insomnia: A Narrative Review.
topicBlack Seed Oil Immune Meta-Analysis
claimInsomnia is increasingly recognized as a manifestation of multisystem dysregulation characterized by sustained physiological hyperarousal.
evidence level4
citationKovitkanit P (2026)
sourceMechanistic Pathways Linking Cannabidiol, Hemp Seed Oil and Black Sesame Oil in Hyperarousal Insomnia: A Narrative Review.
topicBlack Seed Oil Immune Meta-Analysis
claimThis review situates insomnia within a framework of reciprocal disturbances across neuroendocrine, inflammatory, and autonomic pathways.
evidence level4
citationKovitkanit P (2026)
sourceMechanistic Pathways Linking Cannabidiol, Hemp Seed Oil and Black Sesame Oil in Hyperarousal Insomnia: A Narrative Review.