Structured evidence table for Bifidobacterium Constipation Meta-Analysis, generated from 2 reusable source documents in the Migaku knowledge base.
| topic | claim | evidence level | citation | source |
|---|---|---|---|---|
| Bifidobacterium Constipation Meta-Analysis | Additionally, sleep deprivation promoted the secretion of the inhibitory neurotransmitter VIP and stress hormone CORT, with their levels increased by 53.1% and 23.8%, respectively. | 4 | Liang Q (2026) | Evaluation of the Intervention Effect of <i>Bifidobacterium longum</i> on Constipation in Sleep-Deprived Mice. |
| Bifidobacterium Constipation Meta-Analysis | The levels of neurotransmitters including 5HT and GABA were reduced by 15.6% and 23.2%, which ultimately led to a decrease in short-chain fatty acid (SCFA) levels. | 4 | Liang Q (2026) | Evaluation of the Intervention Effect of <i>Bifidobacterium longum</i> on Constipation in Sleep-Deprived Mice. |
| Bifidobacterium Constipation Meta-Analysis | It elevated SCFA levels and upregulated the expression of SCFA receptors GPR41 and GPR109A, promoted the expression of BDNF and GDNF, inhibited HDAC activity, increased the abundance of the beneficial bacterium Akkermansia , and reduced the abundance of the harmful intestinal bacterium Alistipes . | 4 | Liang Q (2026) | Evaluation of the Intervention Effect of <i>Bifidobacterium longum</i> on Constipation in Sleep-Deprived Mice. |
| Bifidobacterium Constipation Meta-Analysis | Background/objectives It remains unclear whether sleep deprivation induces constipation. | 4 | Liang Q (2026) | Evaluation of the Intervention Effect of <i>Bifidobacterium longum</i> on Constipation in Sleep-Deprived Mice. |
| Bifidobacterium Constipation Meta-Analysis | Type 2 diabetes mellitusand chronic kidney disease (CKD)are associated with increasing risk of constipation. | 4 | Ikeda Fuki (2026) | Effects of age, sex, and renal function on bowel movement‐improving effects of Bifidobacterium bifidum G9 ‐1 on constipation in patients with type 2 diabetes mellitus and chronic kidney disease: A prespecified subgroup analysis of the BIRDIE study |
| Bifidobacterium Constipation Meta-Analysis | Moreover, in our previous study, the “” (BIRDIE study), the administration of the tablets containing BBG9‐1 (brand name: Biofermin® tablet) for 12 weeks significantly increased the proportion of participants with normal stool consistency and improved bowel movement and QOL in participants with type 2 diabetes mellitus, CKD, and constipation. | 4 | Ikeda Fuki (2026) | Effects of age, sex, and renal function on bowel movement‐improving effects of Bifidobacterium bifidum G9 ‐1 on constipation in patients with type 2 diabetes mellitus and chronic kidney disease: A prespecified subgroup analysis of the BIRDIE study |
| Bifidobacterium Constipation Meta-Analysis | Correlation analysis to explore the factors associated with the primary endpoint was conducted using Pearson's product–moment and Spearman's rank correlation coefficient by transforming the classification of responder/nonresponder to an ordinal variable, with nonresponder = 0 and responder = 1. | 4 | Ikeda Fuki (2026) | Effects of age, sex, and renal function on bowel movement‐improving effects of Bifidobacterium bifidum G9 ‐1 on constipation in patients with type 2 diabetes mellitus and chronic kidney disease: A prespecified subgroup analysis of the BIRDIE study |
| Bifidobacterium Constipation Meta-Analysis | As constipation lowers quality of life (QOL),and increases the financial burden on patients,,it remains an important clinical issue. | 4 | Ikeda Fuki (2026) | Effects of age, sex, and renal function on bowel movement‐improving effects of Bifidobacterium bifidum G9 ‐1 on constipation in patients with type 2 diabetes mellitus and chronic kidney disease: A prespecified subgroup analysis of the BIRDIE study |
Source documents