exercise performance

Betaine Resistance Exercise Randomized Trial Evidence Table

Structured evidence table for Betaine Resistance Exercise Randomized Trial, generated from 2 reusable source documents in the Migaku knowledge base.

topicclaimevidence levelcitationsource
Betaine Resistance Exercise Randomized TrialEmerging empirical evidence indicates that a simultaneous approach targeting mitochondrial function, one-carbon metabolism, and catecholaminergic pathways may yield a more efficacious strategy than isolated interventions ().3Xu Chunhong (2026)Skeletal muscle mitochondrial–methylation–neurotransmitter crosstalk: a novel synergistic model of betaine, tyrosine, and Cordyceps for exercise performance in older adults, individuals with metabolic disorders, and healthy populations
Betaine Resistance Exercise Randomized TrialThe dysregulation of methylation pathways has been associated with the onset of metabolic syndrome, cognitive decline, and muscular dysfunction ().3Xu Chunhong (2026)Skeletal muscle mitochondrial–methylation–neurotransmitter crosstalk: a novel synergistic model of betaine, tyrosine, and Cordyceps for exercise performance in older adults, individuals with metabolic disorders, and healthy populations
Betaine Resistance Exercise Randomized TrialThe process of aging, along with metabolic disorders, is often correlated with compromised dopaminergic signaling, which contributes to diminished physical performance and increased levels of fatigue.3Xu Chunhong (2026)Skeletal muscle mitochondrial–methylation–neurotransmitter crosstalk: a novel synergistic model of betaine, tyrosine, and Cordyceps for exercise performance in older adults, individuals with metabolic disorders, and healthy populations
Betaine Resistance Exercise Randomized Trial1 2 3 4 5 6 7 8 9 Athletic performance represents a multifaceted phenotype influenced by the interplay of mitochondrial bioenergetics, epigenetic modulation, and neurotransmitter signaling ().3Xu Chunhong (2026)Skeletal muscle mitochondrial–methylation–neurotransmitter crosstalk: a novel synergistic model of betaine, tyrosine, and Cordyceps for exercise performance in older adults, individuals with metabolic disorders, and healthy populations
Betaine Resistance Exercise Randomized TrialObjective This study examined the effects of short-term betaine supplementation on muscle endurance, plasma lactate, testosterone and cortisol levels, and the testosterone to cortisol (T/C) ratio in response to acute resistance exercise (RE).4Arazi H (2022)Effects of short-term betaine supplementation on muscle endurance and indices of endocrine function following acute high-intensity resistance exercise in young athletes.
Betaine Resistance Exercise Randomized TrialMethod Using a double-blind, crossover study design, 10 handball players (age ± SD = 16 ± 1 yrs) without prior-structured RE experience performed a high-intensity RE session (leg press followed by bench press; 5 sets to volitional fatigue using 80% baseline 1 repetition maximum (1RM)), before and after 14 days of either placebo (maltodextrin) or betaine (2.5 g·d -1 ) supplementation.4Arazi H (2022)Effects of short-term betaine supplementation on muscle endurance and indices of endocrine function following acute high-intensity resistance exercise in young athletes.
topicBetaine Resistance Exercise Randomized Trial
claimEmerging empirical evidence indicates that a simultaneous approach targeting mitochondrial function, one-carbon metabolism, and catecholaminergic pathways may yield a more efficacious strategy than isolated interventions ().
evidence level3
citationXu Chunhong (2026)
sourceSkeletal muscle mitochondrial–methylation–neurotransmitter crosstalk: a novel synergistic model of betaine, tyrosine, and Cordyceps for exercise performance in older adults, individuals with metabolic disorders, and healthy populations
topicBetaine Resistance Exercise Randomized Trial
claimThe dysregulation of methylation pathways has been associated with the onset of metabolic syndrome, cognitive decline, and muscular dysfunction ().
evidence level3
citationXu Chunhong (2026)
sourceSkeletal muscle mitochondrial–methylation–neurotransmitter crosstalk: a novel synergistic model of betaine, tyrosine, and Cordyceps for exercise performance in older adults, individuals with metabolic disorders, and healthy populations
topicBetaine Resistance Exercise Randomized Trial
claimThe process of aging, along with metabolic disorders, is often correlated with compromised dopaminergic signaling, which contributes to diminished physical performance and increased levels of fatigue.
evidence level3
citationXu Chunhong (2026)
sourceSkeletal muscle mitochondrial–methylation–neurotransmitter crosstalk: a novel synergistic model of betaine, tyrosine, and Cordyceps for exercise performance in older adults, individuals with metabolic disorders, and healthy populations
topicBetaine Resistance Exercise Randomized Trial
claim1 2 3 4 5 6 7 8 9 Athletic performance represents a multifaceted phenotype influenced by the interplay of mitochondrial bioenergetics, epigenetic modulation, and neurotransmitter signaling ().
evidence level3
citationXu Chunhong (2026)
sourceSkeletal muscle mitochondrial–methylation–neurotransmitter crosstalk: a novel synergistic model of betaine, tyrosine, and Cordyceps for exercise performance in older adults, individuals with metabolic disorders, and healthy populations
topicBetaine Resistance Exercise Randomized Trial
claimObjective This study examined the effects of short-term betaine supplementation on muscle endurance, plasma lactate, testosterone and cortisol levels, and the testosterone to cortisol (T/C) ratio in response to acute resistance exercise (RE).
evidence level4
citationArazi H (2022)
sourceEffects of short-term betaine supplementation on muscle endurance and indices of endocrine function following acute high-intensity resistance exercise in young athletes.
topicBetaine Resistance Exercise Randomized Trial
claimMethod Using a double-blind, crossover study design, 10 handball players (age ± SD = 16 ± 1 yrs) without prior-structured RE experience performed a high-intensity RE session (leg press followed by bench press; 5 sets to volitional fatigue using 80% baseline 1 repetition maximum (1RM)), before and after 14 days of either placebo (maltodextrin) or betaine (2.5 g·d -1 ) supplementation.
evidence level4
citationArazi H (2022)
sourceEffects of short-term betaine supplementation on muscle endurance and indices of endocrine function following acute high-intensity resistance exercise in young athletes.

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AnswerDoes Betaine Resistance Exercise Randomized Trial work?Legacy library material — check the original sources.AnswerIs Betaine Resistance Exercise Randomized Trial safe?Legacy library material — check the original sources.AnswerWhat does the evidence say about Betaine Resistance Exercise Randomized Trial?Legacy library material — check the original sources.AnswerDoes L-Citrulline Resistance Exercise Randomized Trial work?Legacy library material — check the original sources.

Source documents

  1. Skeletal muscle mitochondrial–methylation–neurotransmitter crosstalk: a novel synergistic model of betaine, tyrosine, and Cordyceps for exercise performance in older adults, individuals with metabolic disorders, and healthy populations
  2. Effects of short-term betaine supplementation on muscle endurance and indices of endocrine function following acute high-intensity resistance exercise in young athletes.