Bergamot Cardiometabolic Meta-Analysis Evidence Table

Structured evidence table for Bergamot Cardiometabolic Meta-Analysis, generated from 2 reusable source documents in the Migaku knowledge base.

topicclaimevidence levelcitationsource
Bergamot Cardiometabolic Meta-AnalysisBergamot ( Citrus bergamia ), a flavonoid-rich nutraceutical, has shown potential cardiometabolic benefits, yet evidence from human trials remains inconsistent.1Chambari M (2026)Bergamot (<i>Citrus bergamia</i>) Supplementation and Cardiovascular Disease Risk Factors: A Systematic Review and Meta-Analysis.
Bergamot Cardiometabolic Meta-AnalysisThis systematic review and dose-response meta-analysis evaluated the effects of bergamot ( Citrus bergamia ) on cardiovascular disease risk factors in adults.1Chambari M (2026)Bergamot (<i>Citrus bergamia</i>) Supplementation and Cardiovascular Disease Risk Factors: A Systematic Review and Meta-Analysis.
Bergamot Cardiometabolic Meta-AnalysisThe certainty of evidence was assessed using the Grading of Recommendations Assessment, Development and Evaluation (GRADE) approach.1Chambari M (2026)Bergamot (<i>Citrus bergamia</i>) Supplementation and Cardiovascular Disease Risk Factors: A Systematic Review and Meta-Analysis.
Bergamot Cardiometabolic Meta-AnalysisBackground Non-alcoholic fatty liver disease (NAFLD) is the most common liver disorder in Western countries, characterized by excessive fat storage in the form of lipid droplets (LDs) in hepatocytes; it is also called Metabolic-Associated Steatotic Liver Disease (MASLD), if coexisting with at least one cardiometabolic risk factor.4Riillo C (2025)Bergamot Polyphenols Reduce Hepatic Lipogenesis While Boosting Autophagy and Short-Chain Fatty Acid Production in a Murine "Cafeteria" Model of MASLD.
Bergamot Cardiometabolic Meta-AnalysisBergamot polyphenols (BPF) have been shown to counteract hepatic LD accumulation through potent lipogenesis suppression and associated metabolic benefits in Wistar rats, but their liver-specific anti-lipogenic effects may be species- and strain-dependent.4Riillo C (2025)Bergamot Polyphenols Reduce Hepatic Lipogenesis While Boosting Autophagy and Short-Chain Fatty Acid Production in a Murine "Cafeteria" Model of MASLD.
Bergamot Cardiometabolic Meta-AnalysisThis was associated with a significant increase in blood glucose, triglycerides, and total cholesterol levels, and a decrease in caecal short-chain fatty acids (SCFAs).4Riillo C (2025)Bergamot Polyphenols Reduce Hepatic Lipogenesis While Boosting Autophagy and Short-Chain Fatty Acid Production in a Murine "Cafeteria" Model of MASLD.
topicBergamot Cardiometabolic Meta-Analysis
claimBergamot ( Citrus bergamia ), a flavonoid-rich nutraceutical, has shown potential cardiometabolic benefits, yet evidence from human trials remains inconsistent.
evidence level1
citationChambari M (2026)
sourceBergamot (<i>Citrus bergamia</i>) Supplementation and Cardiovascular Disease Risk Factors: A Systematic Review and Meta-Analysis.
topicBergamot Cardiometabolic Meta-Analysis
claimThis systematic review and dose-response meta-analysis evaluated the effects of bergamot ( Citrus bergamia ) on cardiovascular disease risk factors in adults.
evidence level1
citationChambari M (2026)
sourceBergamot (<i>Citrus bergamia</i>) Supplementation and Cardiovascular Disease Risk Factors: A Systematic Review and Meta-Analysis.
topicBergamot Cardiometabolic Meta-Analysis
claimThe certainty of evidence was assessed using the Grading of Recommendations Assessment, Development and Evaluation (GRADE) approach.
evidence level1
citationChambari M (2026)
sourceBergamot (<i>Citrus bergamia</i>) Supplementation and Cardiovascular Disease Risk Factors: A Systematic Review and Meta-Analysis.
topicBergamot Cardiometabolic Meta-Analysis
claimBackground Non-alcoholic fatty liver disease (NAFLD) is the most common liver disorder in Western countries, characterized by excessive fat storage in the form of lipid droplets (LDs) in hepatocytes; it is also called Metabolic-Associated Steatotic Liver Disease (MASLD), if coexisting with at least one cardiometabolic risk factor.
evidence level4
citationRiillo C (2025)
sourceBergamot Polyphenols Reduce Hepatic Lipogenesis While Boosting Autophagy and Short-Chain Fatty Acid Production in a Murine "Cafeteria" Model of MASLD.
topicBergamot Cardiometabolic Meta-Analysis
claimBergamot polyphenols (BPF) have been shown to counteract hepatic LD accumulation through potent lipogenesis suppression and associated metabolic benefits in Wistar rats, but their liver-specific anti-lipogenic effects may be species- and strain-dependent.
evidence level4
citationRiillo C (2025)
sourceBergamot Polyphenols Reduce Hepatic Lipogenesis While Boosting Autophagy and Short-Chain Fatty Acid Production in a Murine "Cafeteria" Model of MASLD.
topicBergamot Cardiometabolic Meta-Analysis
claimThis was associated with a significant increase in blood glucose, triglycerides, and total cholesterol levels, and a decrease in caecal short-chain fatty acids (SCFAs).
evidence level4
citationRiillo C (2025)
sourceBergamot Polyphenols Reduce Hepatic Lipogenesis While Boosting Autophagy and Short-Chain Fatty Acid Production in a Murine "Cafeteria" Model of MASLD.

Source documents

  1. Bergamot (<i>Citrus bergamia</i>) Supplementation and Cardiovascular Disease Risk Factors: A Systematic Review and Meta-Analysis.
  2. Bergamot Polyphenols Reduce Hepatic Lipogenesis While Boosting Autophagy and Short-Chain Fatty Acid Production in a Murine "Cafeteria" Model of MASLD.