topicBergamot Cardiometabolic Meta-Analysis
claimBergamot ( Citrus bergamia ), a flavonoid-rich nutraceutical, has shown potential cardiometabolic benefits, yet evidence from human trials remains inconsistent.
evidence level1
citationChambari M (2026)
sourceBergamot (<i>Citrus bergamia</i>) Supplementation and Cardiovascular Disease Risk Factors: A Systematic Review and Meta-Analysis.
topicBergamot Cardiometabolic Meta-Analysis
claimThis systematic review and dose-response meta-analysis evaluated the effects of bergamot ( Citrus bergamia ) on cardiovascular disease risk factors in adults.
evidence level1
citationChambari M (2026)
sourceBergamot (<i>Citrus bergamia</i>) Supplementation and Cardiovascular Disease Risk Factors: A Systematic Review and Meta-Analysis.
topicBergamot Cardiometabolic Meta-Analysis
claimThe certainty of evidence was assessed using the Grading of Recommendations Assessment, Development and Evaluation (GRADE) approach.
evidence level1
citationChambari M (2026)
sourceBergamot (<i>Citrus bergamia</i>) Supplementation and Cardiovascular Disease Risk Factors: A Systematic Review and Meta-Analysis.
topicBergamot Cardiometabolic Meta-Analysis
claimBackground Non-alcoholic fatty liver disease (NAFLD) is the most common liver disorder in Western countries, characterized by excessive fat storage in the form of lipid droplets (LDs) in hepatocytes; it is also called Metabolic-Associated Steatotic Liver Disease (MASLD), if coexisting with at least one cardiometabolic risk factor.
evidence level4
citationRiillo C (2025)
sourceBergamot Polyphenols Reduce Hepatic Lipogenesis While Boosting Autophagy and Short-Chain Fatty Acid Production in a Murine "Cafeteria" Model of MASLD.
topicBergamot Cardiometabolic Meta-Analysis
claimBergamot polyphenols (BPF) have been shown to counteract hepatic LD accumulation through potent lipogenesis suppression and associated metabolic benefits in Wistar rats, but their liver-specific anti-lipogenic effects may be species- and strain-dependent.
evidence level4
citationRiillo C (2025)
sourceBergamot Polyphenols Reduce Hepatic Lipogenesis While Boosting Autophagy and Short-Chain Fatty Acid Production in a Murine "Cafeteria" Model of MASLD.
topicBergamot Cardiometabolic Meta-Analysis
claimThis was associated with a significant increase in blood glucose, triglycerides, and total cholesterol levels, and a decrease in caecal short-chain fatty acids (SCFAs).
evidence level4
citationRiillo C (2025)
sourceBergamot Polyphenols Reduce Hepatic Lipogenesis While Boosting Autophagy and Short-Chain Fatty Acid Production in a Murine "Cafeteria" Model of MASLD.