topicBerberine Lipid Meta-Analysis
claimBerberine lowers both lipids and glucose, yet its role on cardiometabolic disease risk remain unclear.
evidence level2
citationZhao JV (2026)
sourceBerberine signature and cardiometabolic diseases using randomized controlled trial, cohort study and Mendelian randomization.
topicBerberine Lipid Meta-Analysis
claimBased on a randomized controlled trial of berberine (registered in ClinicalTrials.gov on Dec 2018, NCT03770325), leveraging proteomics and sex hormones data, we built a signature reflecting response to berberine using elastic net regression.
evidence level2
citationZhao JV (2026)
sourceBerberine signature and cardiometabolic diseases using randomized controlled trial, cohort study and Mendelian randomization.
topicBerberine Lipid Meta-Analysis
claimThe primary prevention of CVD through the management of dyslipidemia, a major risk factor for CVD, is a critical strategy for improving population health outcomes and reducing the associated economic impact.
evidence level4
citationXia Yuanqing (2026)
sourceCost-effectiveness of statins, berberine, and combination for primary cardiovascular disease prevention in Scotland
topicBerberine Lipid Meta-Analysis
claimStatin use has increased substantially in recent years, with nearly two-thirds of those taking statins for primary prevention.
evidence level4
citationXia Yuanqing (2026)
sourceCost-effectiveness of statins, berberine, and combination for primary cardiovascular disease prevention in Scotland
topicBerberine Lipid Meta-Analysis
claimThe clinical guidelines also recommend statin use among people previously considered at low risk of CVD.
evidence level4
citationXia Yuanqing (2026)
sourceCost-effectiveness of statins, berberine, and combination for primary cardiovascular disease prevention in Scotland
topicBerberine Lipid Meta-Analysis
claim1 2 4 – 5 6 , 7 4 8 10 ,– 11 12 13 16 – Cardiovascular disease (CVD) is the leading cause of morbidity and mortality worldwide, which poses a heavy burden on healthcare.
evidence level4
citationXia Yuanqing (2026)
sourceCost-effectiveness of statins, berberine, and combination for primary cardiovascular disease prevention in Scotland