topicBerberine Blood Pressure Meta-Analysis
claimThis review was based on a narrative literature search designed to identify experimental, clinical, and translational evidence linking natural products with gut barrier integrity, gut microbiota, low-grade inflammation, and metabolic endotoxemia.
evidence level3
citationŠantić Roko (2026)
sourceNatural Bioactive Compounds Targeting Gut Barrier Integrity and Metabolic Endotoxemia in Cardiometabolic Disease: Mechanistic Insights and Translational Perspectives
topicBerberine Blood Pressure Meta-Analysis
claimBecause this article is a narrative review rather than a systematic review, formal risk-of-bias assessment and quantitative evidence synthesis were not performed.
evidence level3
citationŠantić Roko (2026)
sourceNatural Bioactive Compounds Targeting Gut Barrier Integrity and Metabolic Endotoxemia in Cardiometabolic Disease: Mechanistic Insights and Translational Perspectives
topicBerberine Blood Pressure Meta-Analysis
claimOver the past two decades, accumulating evidence has repositioned the gastrointestinal tract from a passive absorptive organ to an immunologically active barrier whose functional state directly influences systemic inflammatory tone and metabolic homeostasis [].
evidence level3
citationŠantić Roko (2026)
sourceNatural Bioactive Compounds Targeting Gut Barrier Integrity and Metabolic Endotoxemia in Cardiometabolic Disease: Mechanistic Insights and Translational Perspectives
topicBerberine Blood Pressure Meta-Analysis
claimReference lists of relevant reviews and primary studies were additionally screened to identify articles not captured by database searches.
evidence level3
citationŠantić Roko (2026)
sourceNatural Bioactive Compounds Targeting Gut Barrier Integrity and Metabolic Endotoxemia in Cardiometabolic Disease: Mechanistic Insights and Translational Perspectives
topicBerberine Blood Pressure Meta-Analysis
claimThe primary prevention of CVD through the management of dyslipidemia, a major risk factor for CVD, is a critical strategy for improving population health outcomes and reducing the associated economic impact.
evidence level4
citationXia Yuanqing (2026)
sourceCost-effectiveness of statins, berberine, and combination for primary cardiovascular disease prevention in Scotland
topicBerberine Blood Pressure Meta-Analysis
claimStatin use has increased substantially in recent years, with nearly two-thirds of those taking statins for primary prevention.
evidence level4
citationXia Yuanqing (2026)
sourceCost-effectiveness of statins, berberine, and combination for primary cardiovascular disease prevention in Scotland
topicBerberine Blood Pressure Meta-Analysis
claimThe clinical guidelines also recommend statin use among people previously considered at low risk of CVD.
evidence level4
citationXia Yuanqing (2026)
sourceCost-effectiveness of statins, berberine, and combination for primary cardiovascular disease prevention in Scotland
topicBerberine Blood Pressure Meta-Analysis
claim1 2 4 – 5 6 , 7 4 8 10 ,– 11 12 13 16 – Cardiovascular disease (CVD) is the leading cause of morbidity and mortality worldwide, which poses a heavy burden on healthcare.
evidence level4
citationXia Yuanqing (2026)
sourceCost-effectiveness of statins, berberine, and combination for primary cardiovascular disease prevention in Scotland