topicBerberine Blood Glucose Randomized Trial
claimPrediabetes is defined as an intermediate metabolic state characterized by impaired fasting glucose and/or impaired glucose tolerance, associated with a high risk of progression to diabetes and vascular dysfunction [,].
evidence level1
citationMuacevic Alexander (2026)
sourceA Systematic Review of Herbal Medicines in the Management of Diabetes: Efficacy, Toxicological Profiles, and Clinical Safety Considerations
topicBerberine Blood Glucose Randomized Trial
claimHowever, long-term use of conventional antidiabetic agents has been associated with adverse effects, reduced tolerance, and diminished efficacy in certain populations [,].
evidence level1
citationMuacevic Alexander (2026)
sourceA Systematic Review of Herbal Medicines in the Management of Diabetes: Efficacy, Toxicological Profiles, and Clinical Safety Considerations
topicBerberine Blood Glucose Randomized Trial
claim12 13 14 15 16 17 18 Aloe vera Evidence from both clinical studies (involving human participants) and preclinical studies (including in vivo and in vitro experimental models) indicates that several herbal medicines exhibit antihyperglycaemic effects through multiple biological mechanisms [,].
evidence level1
citationMuacevic Alexander (2026)
sourceA Systematic Review of Herbal Medicines in the Management of Diabetes: Efficacy, Toxicological Profiles, and Clinical Safety Considerations
topicBerberine Blood Glucose Randomized Trial
claim1 2 3 4 5 6 7 8 9 8 10 11 Diabetes mellitus is a persistent metabolic condition characterized by chronic hyperglycemia resulting from defects in insulin secretion, insulin action, or both [].
evidence level1
citationMuacevic Alexander (2026)
sourceA Systematic Review of Herbal Medicines in the Management of Diabetes: Efficacy, Toxicological Profiles, and Clinical Safety Considerations
topicBerberine Blood Glucose Randomized Trial
claimBerberine lowers both lipids and glucose, yet its role on cardiometabolic disease risk remain unclear.
evidence level2
citationZhao JV (2026)
sourceBerberine signature and cardiometabolic diseases using randomized controlled trial, cohort study and Mendelian randomization.
topicBerberine Blood Glucose Randomized Trial
claimBased on a randomized controlled trial of berberine (registered in ClinicalTrials.gov on Dec 2018, NCT03770325), leveraging proteomics and sex hormones data, we built a signature reflecting response to berberine using elastic net regression.
evidence level2
citationZhao JV (2026)
sourceBerberine signature and cardiometabolic diseases using randomized controlled trial, cohort study and Mendelian randomization.