evidence table

Bacopa Sleep Randomized Trial Evidence Table

Structured evidence table for Bacopa Sleep Randomized Trial, generated from 2 reusable source documents in the Migaku knowledge base.

topicclaimevidence levelcitationsource
Bacopa Sleep Randomized TrialNew evidence shows that the gut–brain axis is a crucial modulator: intestinal dysbiosis and increased gut permeability may allow bacterial components (including lipopolysaccharide, LPS) and other metabolites to enter the circulation, triggering systemic inflammation and microglial activation in the brain.4Olajide Abosede Temitope (2026)Phytochemical Profile, Antioxidant Activity, and Neuroprotective Effects of Bacopa monnieri Extract in a Lipopolysaccharide-Induced Dementia Model
Bacopa Sleep Randomized TrialIn addition, the oxygen radical antioxidant capacity (ORAC) assay revealed free radical scavenging capacity of 1.17 ± 0.01 µM TE/mg extract.C,D also shows the kinetic fluorescence decay curves of fluorescein and the net area under the curve (AUC), which also gives additional evidence on the antioxidant potential of the extract.4Olajide Abosede Temitope (2026)Phytochemical Profile, Antioxidant Activity, and Neuroprotective Effects of Bacopa monnieri Extract in a Lipopolysaccharide-Induced Dementia Model
Bacopa Sleep Randomized TrialIn contrast, spontaneous alternation behavior, an indicator of working memory, was slightly reduced in the BME group (60.38 ± 6.05%) compared with the LPS (69.46 ± 8.53%), representing a 0.87% decrease, although this difference was not statistically significant (> 0.05;D).4Olajide Abosede Temitope (2026)Phytochemical Profile, Antioxidant Activity, and Neuroprotective Effects of Bacopa monnieri Extract in a Lipopolysaccharide-Induced Dementia Model
Bacopa Sleep Randomized Trial1 2 3 4 Dementia is a neurodegenerative syndrome, a progressive condition characterized by memory loss as well as other cognitive impairments that significantly affect daily activities and quality of life [].4Olajide Abosede Temitope (2026)Phytochemical Profile, Antioxidant Activity, and Neuroprotective Effects of Bacopa monnieri Extract in a Lipopolysaccharide-Induced Dementia Model
Bacopa Sleep Randomized TrialBy synthesizing molecular evidence from the BDNF/TrkB/CREB signaling axis and the Nrf2/NF-κB homeostatic switch, we demonstrate that this multi-target strategy offers a more robust path to neuronal resilience than traditional single-target approaches.4Cipriano GL (2026)Phytochemical and Fungal Bioactive Compounds in the "Brain Health Triad": A Narrative Review on Neurostimulating, Neurotrophic, and Neuroprotective Synergy.
Bacopa Sleep Randomized TrialThis narrative review proposes the 'Brain Health Triad' as a novel integrative framework for neurorehabilitation and cognitive enhancement, built upon three interdependent biological pillars: neurostimulation, neurotrophy, and neuroprotection.4Cipriano GL (2026)Phytochemical and Fungal Bioactive Compounds in the "Brain Health Triad": A Narrative Review on Neurostimulating, Neurotrophic, and Neuroprotective Synergy.
Bacopa Sleep Randomized TrialWe illustrate how the synergistic interplay between a 'core triad' composed of Hericium erinaceus , Bacopa monnieri , and L-Theanine targets these pillars with high specificity.4Cipriano GL (2026)Phytochemical and Fungal Bioactive Compounds in the "Brain Health Triad": A Narrative Review on Neurostimulating, Neurotrophic, and Neuroprotective Synergy.
topicBacopa Sleep Randomized Trial
claimNew evidence shows that the gut–brain axis is a crucial modulator: intestinal dysbiosis and increased gut permeability may allow bacterial components (including lipopolysaccharide, LPS) and other metabolites to enter the circulation, triggering systemic inflammation and microglial activation in the brain.
evidence level4
citationOlajide Abosede Temitope (2026)
sourcePhytochemical Profile, Antioxidant Activity, and Neuroprotective Effects of Bacopa monnieri Extract in a Lipopolysaccharide-Induced Dementia Model
topicBacopa Sleep Randomized Trial
claimIn addition, the oxygen radical antioxidant capacity (ORAC) assay revealed free radical scavenging capacity of 1.17 ± 0.01 µM TE/mg extract.C,D also shows the kinetic fluorescence decay curves of fluorescein and the net area under the curve (AUC), which also gives additional evidence on the antioxidant potential of the extract.
evidence level4
citationOlajide Abosede Temitope (2026)
sourcePhytochemical Profile, Antioxidant Activity, and Neuroprotective Effects of Bacopa monnieri Extract in a Lipopolysaccharide-Induced Dementia Model
topicBacopa Sleep Randomized Trial
claimIn contrast, spontaneous alternation behavior, an indicator of working memory, was slightly reduced in the BME group (60.38 ± 6.05%) compared with the LPS (69.46 ± 8.53%), representing a 0.87% decrease, although this difference was not statistically significant (> 0.05;D).
evidence level4
citationOlajide Abosede Temitope (2026)
sourcePhytochemical Profile, Antioxidant Activity, and Neuroprotective Effects of Bacopa monnieri Extract in a Lipopolysaccharide-Induced Dementia Model
topicBacopa Sleep Randomized Trial
claim1 2 3 4 Dementia is a neurodegenerative syndrome, a progressive condition characterized by memory loss as well as other cognitive impairments that significantly affect daily activities and quality of life [].
evidence level4
citationOlajide Abosede Temitope (2026)
sourcePhytochemical Profile, Antioxidant Activity, and Neuroprotective Effects of Bacopa monnieri Extract in a Lipopolysaccharide-Induced Dementia Model
topicBacopa Sleep Randomized Trial
claimBy synthesizing molecular evidence from the BDNF/TrkB/CREB signaling axis and the Nrf2/NF-κB homeostatic switch, we demonstrate that this multi-target strategy offers a more robust path to neuronal resilience than traditional single-target approaches.
evidence level4
citationCipriano GL (2026)
sourcePhytochemical and Fungal Bioactive Compounds in the "Brain Health Triad": A Narrative Review on Neurostimulating, Neurotrophic, and Neuroprotective Synergy.
topicBacopa Sleep Randomized Trial
claimThis narrative review proposes the 'Brain Health Triad' as a novel integrative framework for neurorehabilitation and cognitive enhancement, built upon three interdependent biological pillars: neurostimulation, neurotrophy, and neuroprotection.
evidence level4
citationCipriano GL (2026)
sourcePhytochemical and Fungal Bioactive Compounds in the "Brain Health Triad": A Narrative Review on Neurostimulating, Neurotrophic, and Neuroprotective Synergy.
topicBacopa Sleep Randomized Trial
claimWe illustrate how the synergistic interplay between a 'core triad' composed of Hericium erinaceus , Bacopa monnieri , and L-Theanine targets these pillars with high specificity.
evidence level4
citationCipriano GL (2026)
sourcePhytochemical and Fungal Bioactive Compounds in the "Brain Health Triad": A Narrative Review on Neurostimulating, Neurotrophic, and Neuroprotective Synergy.

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Source documents

  1. Phytochemical Profile, Antioxidant Activity, and Neuroprotective Effects of Bacopa monnieri Extract in a Lipopolysaccharide-Induced Dementia Model
  2. Phytochemical and Fungal Bioactive Compounds in the "Brain Health Triad": A Narrative Review on Neurostimulating, Neurotrophic, and Neuroprotective Synergy.