topicBacopa Attention Meta-Analysis
claimConclusion The NMA results indicate that in terms of learning and memory functions, raisin and tart cherry ranked higher; in terms of executive functions, the bacopa monnieri compound demonstrated a relatively better intervention effect, providing an important basis for non-drug interventions for cognitive health in the healthy older adults.
evidence level1
citationFeng X (2026)
sourceThe effect of plant active substances on cognitive function in healthy older adults: a systematic review and network meta-analysis of randomized controlled trials.
topicBacopa Attention Meta-Analysis
claimBackground With the accelerating global population aging, age-related cognitive decline has become a significant health concern for the older adults.
evidence level1
citationFeng X (2026)
sourceThe effect of plant active substances on cognitive function in healthy older adults: a systematic review and network meta-analysis of randomized controlled trials.
topicBacopa Attention Meta-Analysis
claimThe limited efficacy and common side effects of pharmacological interventions have made the exploration of safe non-pharmacological strategies an urgent need.
evidence level1
citationFeng X (2026)
sourceThe effect of plant active substances on cognitive function in healthy older adults: a systematic review and network meta-analysis of randomized controlled trials.
topicBacopa Attention Meta-Analysis
claimUnder normal conditions, it is sequestered in the cytoplasm by Kelch-like ECH-associated protein 1 (Keap1), which targets it for degradation [].
evidence level4
citationCipriano Giovanni Luca (2026)
sourcePhytochemical and Fungal Bioactive Compounds in the “Brain Health Triad”: A Narrative Review on Neurostimulating, Neurotrophic, and Neuroprotective Synergy
topicBacopa Attention Meta-Analysis
claimThe following subsections provide a detailed analysis of the molecular profiles and clinical evidence for these three primary bioactives.
evidence level4
citationCipriano Giovanni Luca (2026)
sourcePhytochemical and Fungal Bioactive Compounds in the “Brain Health Triad”: A Narrative Review on Neurostimulating, Neurotrophic, and Neuroprotective Synergy
topicBacopa Attention Meta-Analysis
claimIn elderly patients with mild cognitive impairment (MCI), 16 weeks of Lion’s Mane supplementation significantly improved cognitive scores, with a subsequent decline observed once supplementation ceased, emphasizing its role in maintaining functional neural connectivity [].
evidence level4
citationCipriano Giovanni Luca (2026)
sourcePhytochemical and Fungal Bioactive Compounds in the “Brain Health Triad”: A Narrative Review on Neurostimulating, Neurotrophic, and Neuroprotective Synergy
topicBacopa Attention Meta-Analysis
claim1 2 3 4 5 6 The global increase in life expectancy has led to a parallel rise in the prevalence of neurodegenerative diseases and age-related cognitive decline [,], establishing brain health as a paramount priority in contemporary biomedical research.
evidence level4
citationCipriano Giovanni Luca (2026)
sourcePhytochemical and Fungal Bioactive Compounds in the “Brain Health Triad”: A Narrative Review on Neurostimulating, Neurotrophic, and Neuroprotective Synergy