Ashwagandha and Stress Evidence Table

Structured evidence table for Ashwagandha and Stress, generated from 2 reusable source documents in the Migaku knowledge base.

topicclaimevidence levelcitationsource
Ashwagandha and StressMethodological quality and risk of bias were assessed with RoB 2, evidence certainty for each outcome was evaluated with GRADE system, and botanical reporting was assessed with the ConPhyMP checklist.1Zhu X (2026)Effects of <i>Withania somnifera (L.) Dunal</i> (Ashwagandha) on cognitive and physical function in adults: a systematic review and meta-analysis.
Ashwagandha and StressAshwagandha significantly improved memory (SMD = 0.52; 95% CI: 0.27-0.78; P 2 = 29.7%), attention and processing speed (SMD = 0.29; 95% CI: 0.07-0.51; P = 0.009; I 2 = 0%), and executive function (SMD = -0.42; 95% CI: -0.70 to -0.13; P = 0.004; I 2 = 37.5%).1Zhu X (2026)Effects of <i>Withania somnifera (L.) Dunal</i> (Ashwagandha) on cognitive and physical function in adults: a systematic review and meta-analysis.
Ashwagandha and StressVisuospatial ability improved after excluding one heterogeneous study (SMD = 0.39; 95% CI: 0.08-0.70; P = 0.013; I 2 = 0%).1Zhu X (2026)Effects of <i>Withania somnifera (L.) Dunal</i> (Ashwagandha) on cognitive and physical function in adults: a systematic review and meta-analysis.
Ashwagandha and StressBackground This study aimed to systematically review and evaluate the effects of Withania somnifera (L.) Dunal (Solanaceae) supplementation on cognitive and physical function in adults by meta-analysis.1Zhu X (2026)Effects of <i>Withania somnifera (L.) Dunal</i> (Ashwagandha) on cognitive and physical function in adults: a systematic review and meta-analysis.
Ashwagandha and StressThere is a paucity of evidence assessing the efficacy and safety of low-dose formulations of Ashwagandha in stress management.2Thanawala Shefali (2026)Efficacy and safety of Ashwagandha root extract sustained-release (AshwaSR) capsules in healthy adult, stressed subjects: A randomized, double-blind, placebo-controlled, parallel-group, 3-arm clinical trial
Ashwagandha and StressWe evaluated the efficacy and safety of AshwaSR capsules at doses of 150 and 300 mg in reducing stress and associated symptoms in healthy adults experiencing stress, over a period of 60 days of administration.2Thanawala Shefali (2026)Efficacy and safety of Ashwagandha root extract sustained-release (AshwaSR) capsules in healthy adult, stressed subjects: A randomized, double-blind, placebo-controlled, parallel-group, 3-arm clinical trial
Ashwagandha and StressItems were designed to determine how unpredictable, uncontrollable, and overloaded subjects found their lives, with response scores ranging between 0 and 40 (scores 0–13, low; 14–26, moderate; 27–40, high perceived stress).2Thanawala Shefali (2026)Efficacy and safety of Ashwagandha root extract sustained-release (AshwaSR) capsules in healthy adult, stressed subjects: A randomized, double-blind, placebo-controlled, parallel-group, 3-arm clinical trial
Ashwagandha and Stress1 2 [,] 3 4 [,] 5 [] Stress is a normal response to difficult situations in an individual’s life; however, prolonged and excessive mental or physical stress can be detrimental.2Thanawala Shefali (2026)Efficacy and safety of Ashwagandha root extract sustained-release (AshwaSR) capsules in healthy adult, stressed subjects: A randomized, double-blind, placebo-controlled, parallel-group, 3-arm clinical trial
topicAshwagandha and Stress
claimMethodological quality and risk of bias were assessed with RoB 2, evidence certainty for each outcome was evaluated with GRADE system, and botanical reporting was assessed with the ConPhyMP checklist.
evidence level1
citationZhu X (2026)
sourceEffects of <i>Withania somnifera (L.) Dunal</i> (Ashwagandha) on cognitive and physical function in adults: a systematic review and meta-analysis.
topicAshwagandha and Stress
claimAshwagandha significantly improved memory (SMD = 0.52; 95% CI: 0.27-0.78; P 2 = 29.7%), attention and processing speed (SMD = 0.29; 95% CI: 0.07-0.51; P = 0.009; I 2 = 0%), and executive function (SMD = -0.42; 95% CI: -0.70 to -0.13; P = 0.004; I 2 = 37.5%).
evidence level1
citationZhu X (2026)
sourceEffects of <i>Withania somnifera (L.) Dunal</i> (Ashwagandha) on cognitive and physical function in adults: a systematic review and meta-analysis.
topicAshwagandha and Stress
claimVisuospatial ability improved after excluding one heterogeneous study (SMD = 0.39; 95% CI: 0.08-0.70; P = 0.013; I 2 = 0%).
evidence level1
citationZhu X (2026)
sourceEffects of <i>Withania somnifera (L.) Dunal</i> (Ashwagandha) on cognitive and physical function in adults: a systematic review and meta-analysis.
topicAshwagandha and Stress
claimBackground This study aimed to systematically review and evaluate the effects of Withania somnifera (L.) Dunal (Solanaceae) supplementation on cognitive and physical function in adults by meta-analysis.
evidence level1
citationZhu X (2026)
sourceEffects of <i>Withania somnifera (L.) Dunal</i> (Ashwagandha) on cognitive and physical function in adults: a systematic review and meta-analysis.
topicAshwagandha and Stress
claimThere is a paucity of evidence assessing the efficacy and safety of low-dose formulations of Ashwagandha in stress management.
evidence level2
citationThanawala Shefali (2026)
sourceEfficacy and safety of Ashwagandha root extract sustained-release (AshwaSR) capsules in healthy adult, stressed subjects: A randomized, double-blind, placebo-controlled, parallel-group, 3-arm clinical trial
topicAshwagandha and Stress
claimWe evaluated the efficacy and safety of AshwaSR capsules at doses of 150 and 300 mg in reducing stress and associated symptoms in healthy adults experiencing stress, over a period of 60 days of administration.
evidence level2
citationThanawala Shefali (2026)
sourceEfficacy and safety of Ashwagandha root extract sustained-release (AshwaSR) capsules in healthy adult, stressed subjects: A randomized, double-blind, placebo-controlled, parallel-group, 3-arm clinical trial
topicAshwagandha and Stress
claimItems were designed to determine how unpredictable, uncontrollable, and overloaded subjects found their lives, with response scores ranging between 0 and 40 (scores 0–13, low; 14–26, moderate; 27–40, high perceived stress).
evidence level2
citationThanawala Shefali (2026)
sourceEfficacy and safety of Ashwagandha root extract sustained-release (AshwaSR) capsules in healthy adult, stressed subjects: A randomized, double-blind, placebo-controlled, parallel-group, 3-arm clinical trial
topicAshwagandha and Stress
claim1 2 [,] 3 4 [,] 5 [] Stress is a normal response to difficult situations in an individual’s life; however, prolonged and excessive mental or physical stress can be detrimental.
evidence level2
citationThanawala Shefali (2026)
sourceEfficacy and safety of Ashwagandha root extract sustained-release (AshwaSR) capsules in healthy adult, stressed subjects: A randomized, double-blind, placebo-controlled, parallel-group, 3-arm clinical trial

Source documents

  1. Effects of <i>Withania somnifera (L.) Dunal</i> (Ashwagandha) on cognitive and physical function in adults: a systematic review and meta-analysis.
  2. Efficacy and safety of Ashwagandha root extract sustained-release (AshwaSR) capsules in healthy adult, stressed subjects: A randomized, double-blind, placebo-controlled, parallel-group, 3-arm clinical trial