topicAshwagandha Cortisol Randomized Trial
claimThere is a paucity of evidence assessing the efficacy and safety of low-dose formulations of Ashwagandha in stress management.
evidence level2
citationThanawala Shefali (2026)
sourceEfficacy and safety of Ashwagandha root extract sustained-release (AshwaSR) capsules in healthy adult, stressed subjects: A randomized, double-blind, placebo-controlled, parallel-group, 3-arm clinical trial
topicAshwagandha Cortisol Randomized Trial
claimWe evaluated the efficacy and safety of AshwaSR capsules at doses of 150 and 300 mg in reducing stress and associated symptoms in healthy adults experiencing stress, over a period of 60 days of administration.
evidence level2
citationThanawala Shefali (2026)
sourceEfficacy and safety of Ashwagandha root extract sustained-release (AshwaSR) capsules in healthy adult, stressed subjects: A randomized, double-blind, placebo-controlled, parallel-group, 3-arm clinical trial
topicAshwagandha Cortisol Randomized Trial
claimItems were designed to determine how unpredictable, uncontrollable, and overloaded subjects found their lives, with response scores ranging between 0 and 40 (scores 0–13, low; 14–26, moderate; 27–40, high perceived stress).
evidence level2
citationThanawala Shefali (2026)
sourceEfficacy and safety of Ashwagandha root extract sustained-release (AshwaSR) capsules in healthy adult, stressed subjects: A randomized, double-blind, placebo-controlled, parallel-group, 3-arm clinical trial
topicAshwagandha Cortisol Randomized Trial
claim1 2 [,] 3 4 [,] 5 [] Stress is a normal response to difficult situations in an individual’s life; however, prolonged and excessive mental or physical stress can be detrimental.
evidence level2
citationThanawala Shefali (2026)
sourceEfficacy and safety of Ashwagandha root extract sustained-release (AshwaSR) capsules in healthy adult, stressed subjects: A randomized, double-blind, placebo-controlled, parallel-group, 3-arm clinical trial
topicAshwagandha Cortisol Randomized Trial
claimAim of the study This narrative review aims to evaluate the current evidence regarding the usefulness of Withania somnifera in aiding women's hormonal balance, with a particular focus on its potential applications in PCOS and PMS.
evidence level4
citationNamysł M (2026)
sourceWithania somnifera in Women's Hormonal Modulation: A Narrative Review With Implications for Polycystic Ovary Syndrome and Premenstrual Syndrome.
topicAshwagandha Cortisol Randomized Trial
claimIn PMS, ashwagandha's neuropsychiatric properties, most likely associated with GABAergic signaling and HPA modulation, may be beneficial in lowering fatigue, anxiety, and stress reactivity.
evidence level4
citationNamysł M (2026)
sourceWithania somnifera in Women's Hormonal Modulation: A Narrative Review With Implications for Polycystic Ovary Syndrome and Premenstrual Syndrome.
topicAshwagandha Cortisol Randomized Trial
claimHowever, as current evidence relies heavily on preclinical models and extrapolation from other populations, further large-scale, randomized clinical trials using standardized extracts are necessary to establish definitive therapeutic protocols and confirm its clinical efficacy and safety.
evidence level4
citationNamysł M (2026)
sourceWithania somnifera in Women's Hormonal Modulation: A Narrative Review With Implications for Polycystic Ovary Syndrome and Premenstrual Syndrome.
topicAshwagandha Cortisol Randomized Trial
claimBackground Polycystic ovary syndrome (PCOS) and premenstrual syndrome (PMS) are among the most common hormonal diseases affecting women worldwide.
evidence level4
citationNamysł M (2026)
sourceWithania somnifera in Women's Hormonal Modulation: A Narrative Review With Implications for Polycystic Ovary Syndrome and Premenstrual Syndrome.