topicApigenin Sleep Randomized Trial
claimWe integrate evidence from clinical studies, animal models, and in vitro experiments and organize the discussion around the central pathological processes of dementia.
evidence level3
citationZhang Shi‐qi (2026)
sourceNAD + ‒circadian rhythm coupling in dementia
topicApigenin Sleep Randomized Trial
claimWe excluded studies that did not address these core themes, provided insufficient evidence, or offered limited translational relevance.
evidence level3
citationZhang Shi‐qi (2026)
sourceNAD + ‒circadian rhythm coupling in dementia
topicApigenin Sleep Randomized Trial
claimOn this basis, we distinguish mechanisms supported by direct evidence from those that remain inferential, highlight testable hypotheses with translational relevance, and identify subtype‐specific molecular nodes that may guide future intervention studies.
evidence level3
citationZhang Shi‐qi (2026)
sourceNAD + ‒circadian rhythm coupling in dementia
topicApigenin Sleep Randomized Trial
claimSleep supports stable brain and body function by aligning physiology with the light‐dark cycle.
evidence level3
citationZhang Shi‐qi (2026)
sourceNAD + ‒circadian rhythm coupling in dementia
topicApigenin Sleep Randomized Trial
claimSleep is a complex biological process whose evolutionary purpose has remained equivocal for quite some time.More recently, however, compelling evidence has emerged, leading to recognition of the numerous metabolic and physiological functions sleep contributes to and actively supports.
evidence level4
citationConti Federica (2026)
sourceDietary Protocols to Promote and Improve Restful Sleep: A Narrative Review
topicApigenin Sleep Randomized Trial
claimEpidemiological studies have revealed that sleep deprivation is associated with an increased risk of all-cause mortality,alongside numerous chronic conditions imposing a heavy burden on our healthcare and socioeconomic systems alike,including cardiovascular disease, stroke, obesity, type 2 diabetes, and various types of cancer and neurological disorders.
evidence level4
citationConti Federica (2026)
sourceDietary Protocols to Promote and Improve Restful Sleep: A Narrative Review
topicApigenin Sleep Randomized Trial
claimThe scope of this narrative review is to summarize the available evidence on the mechanisms of action and potential benefits of the above-listed nutrients in the context of acute or chronic sleep disturbances.
evidence level4
citationConti Federica (2026)
sourceDietary Protocols to Promote and Improve Restful Sleep: A Narrative Review
topicApigenin Sleep Randomized Trial
claim, , Over the past few decades, there has been an increasing appreciation of the negative impact of sleep disturbances and circadian misalignments on all aspects of human health and performance, ranging from objective alertness, learning, memory, and cognition to emotional regulation, social wellbeing and, most remarkably, physical health.
evidence level4
citationConti Federica (2026)
sourceDietary Protocols to Promote and Improve Restful Sleep: A Narrative Review