metabolic health

Amla Cholesterol Randomized Trial Evidence Table

Structured evidence table for Amla Cholesterol Randomized Trial, generated from 2 reusable source documents in the Migaku knowledge base.

topicclaimevidence levelcitationsource
Amla Cholesterol Randomized TrialDysregulation of this axis contributes to hypercholesterolemia and cardiometabolic risk, beyond classical cholesterol synthesis pathways.4Uberti F (2026)Natural Extract Combination Modulates Intestinal Barrier and Hepatic Cholesterol via the Gut-Liver Axis In Vitro.
Amla Cholesterol Randomized TrialIn HepG2 cells, MIX demonstrated synergistic effects: it reduced HMGR expression by 83-90% relative to individual extracts, increased LDLR expression by 43-97%, suppressed PCSK9 by up to 92%, and lowered total cholesterol and LDL uptake more effectively than RYRF.4Uberti F (2026)Natural Extract Combination Modulates Intestinal Barrier and Hepatic Cholesterol via the Gut-Liver Axis In Vitro.
Amla Cholesterol Randomized TrialMIX also amplified bile acid production and free cholesterol excretion, indicating improved hepatic clearance pathways.4Uberti F (2026)Natural Extract Combination Modulates Intestinal Barrier and Hepatic Cholesterol via the Gut-Liver Axis In Vitro.
Amla Cholesterol Randomized TrialBackground/Objectives: The gut-liver axis plays a central role in cholesterol homeostasis, linking intestinal absorption, microbial metabolites, and hepatic lipid regulation.4Uberti F (2026)Natural Extract Combination Modulates Intestinal Barrier and Hepatic Cholesterol via the Gut-Liver Axis In Vitro.
Amla Cholesterol Randomized TrialBackground Dyslipidemia, marked by abnormal lipid levels, significantly increases the risk of cardiovascular diseases.4Jagalurappa K (2025)Effect of <i>Emblica officinalis</i> (Amla) Extract Versus Exercise on Lipid Levels in Participants With Abnormal Lipid Levels: An Open-Label Clinical Study.
Amla Cholesterol Randomized TrialEffective management of these lipid abnormalities is essential for reducing cardiovascular risk.4Jagalurappa K (2025)Effect of <i>Emblica officinalis</i> (Amla) Extract Versus Exercise on Lipid Levels in Participants With Abnormal Lipid Levels: An Open-Label Clinical Study.
Amla Cholesterol Randomized TrialResults Amla extract over a period of 90 days significantly reduced triglyceride ( P = 0.007), total cholesterol ( P P = 0.006), VLDL ( P = 0.014), and AIP ( P P = 0.967) and fasting blood sugar ( P = 1.00).4Jagalurappa K (2025)Effect of <i>Emblica officinalis</i> (Amla) Extract Versus Exercise on Lipid Levels in Participants With Abnormal Lipid Levels: An Open-Label Clinical Study.
topicAmla Cholesterol Randomized Trial
claimDysregulation of this axis contributes to hypercholesterolemia and cardiometabolic risk, beyond classical cholesterol synthesis pathways.
evidence level4
citationUberti F (2026)
sourceNatural Extract Combination Modulates Intestinal Barrier and Hepatic Cholesterol via the Gut-Liver Axis In Vitro.
topicAmla Cholesterol Randomized Trial
claimIn HepG2 cells, MIX demonstrated synergistic effects: it reduced HMGR expression by 83-90% relative to individual extracts, increased LDLR expression by 43-97%, suppressed PCSK9 by up to 92%, and lowered total cholesterol and LDL uptake more effectively than RYRF.
evidence level4
citationUberti F (2026)
sourceNatural Extract Combination Modulates Intestinal Barrier and Hepatic Cholesterol via the Gut-Liver Axis In Vitro.
topicAmla Cholesterol Randomized Trial
claimMIX also amplified bile acid production and free cholesterol excretion, indicating improved hepatic clearance pathways.
evidence level4
citationUberti F (2026)
sourceNatural Extract Combination Modulates Intestinal Barrier and Hepatic Cholesterol via the Gut-Liver Axis In Vitro.
topicAmla Cholesterol Randomized Trial
claimBackground/Objectives: The gut-liver axis plays a central role in cholesterol homeostasis, linking intestinal absorption, microbial metabolites, and hepatic lipid regulation.
evidence level4
citationUberti F (2026)
sourceNatural Extract Combination Modulates Intestinal Barrier and Hepatic Cholesterol via the Gut-Liver Axis In Vitro.
topicAmla Cholesterol Randomized Trial
claimBackground Dyslipidemia, marked by abnormal lipid levels, significantly increases the risk of cardiovascular diseases.
evidence level4
citationJagalurappa K (2025)
sourceEffect of <i>Emblica officinalis</i> (Amla) Extract Versus Exercise on Lipid Levels in Participants With Abnormal Lipid Levels: An Open-Label Clinical Study.
topicAmla Cholesterol Randomized Trial
claimEffective management of these lipid abnormalities is essential for reducing cardiovascular risk.
evidence level4
citationJagalurappa K (2025)
sourceEffect of <i>Emblica officinalis</i> (Amla) Extract Versus Exercise on Lipid Levels in Participants With Abnormal Lipid Levels: An Open-Label Clinical Study.
topicAmla Cholesterol Randomized Trial
claimResults Amla extract over a period of 90 days significantly reduced triglyceride ( P = 0.007), total cholesterol ( P P = 0.006), VLDL ( P = 0.014), and AIP ( P P = 0.967) and fasting blood sugar ( P = 1.00).
evidence level4
citationJagalurappa K (2025)
sourceEffect of <i>Emblica officinalis</i> (Amla) Extract Versus Exercise on Lipid Levels in Participants With Abnormal Lipid Levels: An Open-Label Clinical Study.

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Source documents

  1. Natural Extract Combination Modulates Intestinal Barrier and Hepatic Cholesterol via the Gut-Liver Axis In Vitro.
  2. Effect of <i>Emblica officinalis</i> (Amla) Extract Versus Exercise on Lipid Levels in Participants With Abnormal Lipid Levels: An Open-Label Clinical Study.