Structured evidence table for Acetyl-L-Carnitine Cognitive Performance Meta-Analysis, generated from 2 reusable source documents in the Migaku knowledge base.
| topic | claim | evidence level | citation | source |
|---|---|---|---|---|
| Acetyl-L-Carnitine Cognitive Performance Meta-Analysis | Acetyl-l-carnitine long-term neurotrophic and analgesic activity is supported by evidence from both preclinical models and clinical studies in peripheral neuropathies. | 4 | Fornasari Diego Maria Michele (2026) | Acetyl- l -Carnitine in the Treatment of Peripheral Neuropathies: A Narrative Review |
| Acetyl-L-Carnitine Cognitive Performance Meta-Analysis | It is also found in several foods, with red meats, such as beef and lamb, being its richest sources. | 4 | Fornasari Diego Maria Michele (2026) | Acetyl- l -Carnitine in the Treatment of Peripheral Neuropathies: A Narrative Review |
| Acetyl-L-Carnitine Cognitive Performance Meta-Analysis | There is evidence for benefits of treatment with acetyl--carnitine in conditions such as neuropathy, depression, neurodegenerative disorders, and others [,]. | 4 | Fornasari Diego Maria Michele (2026) | Acetyl- l -Carnitine in the Treatment of Peripheral Neuropathies: A Narrative Review |
| Acetyl-L-Carnitine Cognitive Performance Meta-Analysis | Exogenous acetyl-l-carnitine exerts its neuroprotective and neurotrophic effects through its antioxidant and metabolic properties. | 4 | Fornasari Diego Maria Michele (2026) | Acetyl- l -Carnitine in the Treatment of Peripheral Neuropathies: A Narrative Review |
| Acetyl-L-Carnitine Cognitive Performance Meta-Analysis | Mendelian randomization (MR) presents a causal inference methodology to examine the effect of modifiable exposure on a disease by leveraging genetic variants to provide evidence of robust associations. | 4 | Luan Sisi (2025) | The Effect of Acylcarnitines on Cognitive Function: A Two‐Sample Mendelian Randomization Study |
| Acetyl-L-Carnitine Cognitive Performance Meta-Analysis | S1 Our study adopted the TSMR design, an approach that leverages genetic variants as instrumental variables and utilizes summary statistics from two independent samples, which could minimize confounding and reverse causation and provide more robust evidence for causality. | 4 | Luan Sisi (2025) | The Effect of Acylcarnitines on Cognitive Function: A Two‐Sample Mendelian Randomization Study |
| Acetyl-L-Carnitine Cognitive Performance Meta-Analysis | Index SNPs (< 0.01 with any other associated SNPs within 10 Mb) with the lowest‐value were retained. | 4 | Luan Sisi (2025) | The Effect of Acylcarnitines on Cognitive Function: A Two‐Sample Mendelian Randomization Study |
| Acetyl-L-Carnitine Cognitive Performance Meta-Analysis | 2020 2019 2015 2021 2011 2014 Cognitive dysfunction is defined as deficits in one or more cognitive domains, including but not limited to memory, executive function, language, and spatial ability (Srikanth et al.). | 4 | Luan Sisi (2025) | The Effect of Acylcarnitines on Cognitive Function: A Two‐Sample Mendelian Randomization Study |
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