Quick Answer
Vitamin D Exercise Recovery Randomized Trial has evidence relevant to strength of evidence and what the studies can or cannot prove, but conclusions should stay close to the cited sources. One representative finding is: However, human evidence remains limited, particularly with regard to whether short-term vitamin Dsupplementation can modify resting inflammatory status and the acute inflammatory response to repeated supramaximal exercise.
Key Takeaways
- 01However, human evidence remains limited, particularly with regard to whether short-term vitamin Dsupplementation can modify resting inflammatory status and the acute inflammatory response to repeated supramaximal exercise. [Grześkiewicz Katarzyna (2026)]
- 02After 21 days, resting 25(OH)D increased in the vitamin Dgroup by +55.7% (p < 0.001), whereas no significant change was observed in placebo (+0.5%, p = 1.000). [Grześkiewicz Katarzyna (2026)]
- 033 3 3 3 3 For inflammatory biomarkers, significant Group × supplementation phase interactions were observed for IL-1β, IL-6, and IL-10, whereas no interaction was found for IL-1RA. [Grześkiewicz Katarzyna (2026)]
- 04Mieszkowski et al., 2021a Stankiewicz et al., 2023 McFadden et al., 2022 Nemkov et al., 2025 An excessive inflammatory response to strenuous exercise is increasingly recognized as a factor that may impair athletic performance, recovery, and overall athlete health (;). [Grześkiewicz Katarzyna (2026)]
The current Migaku evidence database contains 2 reusable source documents for Vitamin D Exercise Recovery Randomized Trial. This answer focuses on strength of evidence and what the studies can or cannot prove.
- However, human evidence remains limited, particularly with regard to whether short-term vitamin Dsupplementation can modify resting inflammatory status and the acute inflammatory response to repeated supramaximal exercise. [Grześkiewicz Katarzyna (2026); evidence level 2]
- After 21 days, resting 25(OH)D increased in the vitamin Dgroup by +55.7% (p < 0.001), whereas no significant change was observed in placebo (+0.5%, p = 1.000). [Grześkiewicz Katarzyna (2026); evidence level 2]
- 3 3 3 3 3 For inflammatory biomarkers, significant Group × supplementation phase interactions were observed for IL-1β, IL-6, and IL-10, whereas no interaction was found for IL-1RA. [Grześkiewicz Katarzyna (2026); evidence level 2]
- Mieszkowski et al., 2021a Stankiewicz et al., 2023 McFadden et al., 2022 Nemkov et al., 2025 An excessive inflammatory response to strenuous exercise is increasingly recognized as a factor that may impair athletic performance, recovery, and overall athlete health (;). [Grześkiewicz Katarzyna (2026); evidence level 2]
- Objective This narrative review synthesizes mechanistic and clinical evidence examining whether vitamin D status and supplementation are associated with modulation of selected exercise-responsive exerkines, and it introduces a unifying conceptual model, the "vitamin D-exerkine axis", to frame potential points of interaction between vitamin D signaling and the exercise-induced secretome. [Kim DH (2026); evidence level 4]
Evidence levels are sorting aids, not final clinical grades. Level 1 usually indicates systematic-review style evidence, level 2 indicates randomized trials or public-health guidance, and lower levels need more cautious wording.
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