Quick Answer
Vitamin D Exercise Recovery Randomized Trial has evidence relevant to benefits, uncertainty, and practical interpretation, but conclusions should stay close to the cited sources. One representative finding is: However, human evidence remains limited, particularly with regard to whether short-term vitamin Dsupplementation can modify resting inflammatory status and the acute inflammatory response to repeated supramaximal exercise.
Key Takeaways
- 01However, human evidence remains limited, particularly with regard to whether short-term vitamin Dsupplementation can modify resting inflammatory status and the acute inflammatory response to repeated supramaximal exercise. [Grześkiewicz Katarzyna (2026)]
- 02After 21 days, resting 25(OH)D increased in the vitamin Dgroup by +55.7% (p < 0.001), whereas no significant change was observed in placebo (+0.5%, p = 1.000). [Grześkiewicz Katarzyna (2026)]
- 033 3 3 3 3 For inflammatory biomarkers, significant Group × supplementation phase interactions were observed for IL-1β, IL-6, and IL-10, whereas no interaction was found for IL-1RA. [Grześkiewicz Katarzyna (2026)]
- 04Mieszkowski et al., 2021a Stankiewicz et al., 2023 McFadden et al., 2022 Nemkov et al., 2025 An excessive inflammatory response to strenuous exercise is increasingly recognized as a factor that may impair athletic performance, recovery, and overall athlete health (;). [Grześkiewicz Katarzyna (2026)]
The current Migaku evidence database contains 2 reusable source documents for Vitamin D Exercise Recovery Randomized Trial. This answer focuses on benefits, uncertainty, and practical interpretation.
- However, human evidence remains limited, particularly with regard to whether short-term vitamin Dsupplementation can modify resting inflammatory status and the acute inflammatory response to repeated supramaximal exercise. [Grześkiewicz Katarzyna (2026); evidence level 2]
- After 21 days, resting 25(OH)D increased in the vitamin Dgroup by +55.7% (p < 0.001), whereas no significant change was observed in placebo (+0.5%, p = 1.000). [Grześkiewicz Katarzyna (2026); evidence level 2]
- 3 3 3 3 3 For inflammatory biomarkers, significant Group × supplementation phase interactions were observed for IL-1β, IL-6, and IL-10, whereas no interaction was found for IL-1RA. [Grześkiewicz Katarzyna (2026); evidence level 2]
- Mieszkowski et al., 2021a Stankiewicz et al., 2023 McFadden et al., 2022 Nemkov et al., 2025 An excessive inflammatory response to strenuous exercise is increasingly recognized as a factor that may impair athletic performance, recovery, and overall athlete health (;). [Grześkiewicz Katarzyna (2026); evidence level 2]
- Objective This narrative review synthesizes mechanistic and clinical evidence examining whether vitamin D status and supplementation are associated with modulation of selected exercise-responsive exerkines, and it introduces a unifying conceptual model, the "vitamin D-exerkine axis", to frame potential points of interaction between vitamin D signaling and the exercise-induced secretome. [Kim DH (2026); evidence level 4]
Evidence levels are sorting aids, not final clinical grades. Level 1 usually indicates systematic-review style evidence, level 2 indicates randomized trials or public-health guidance, and lower levels need more cautious wording.
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Sources