What does the evidence say about Vitamin B6 Exercise Fatigue Randomized Trial?

Updated October 2026

Quick Answer

Vitamin B6 Exercise Fatigue Randomized Trial has evidence relevant to benefits, uncertainty, and practical interpretation, but conclusions should stay close to the cited sources. One representative finding is: Based on the evidence presented above, we hypothesized that a 28-day supplementation of vitamin B would enhance physical performance and reduce physical fatigue.

Key Takeaways

  • 01Based on the evidence presented above, we hypothesized that a 28-day supplementation of vitamin B would enhance physical performance and reduce physical fatigue. [Lee MC (2023)]
  • 02After supplementation with Ex PLUS ® , we found a significant increase in the running time by 1.26-fold ( p 0.05) to exhaustion compared to that before supplementation and that in the placebo group. [Lee MC (2023)]
  • 03In addition, the Ex PLUS ® supplementation group presented significantly reduced blood lactate and blood ammonia concentrations during exercise and at rest after exercise compared with placebo ( p ® ) supplementation significantly improved exercise endurance performance and reduced exercise fatigue biochemical metabolites in not athletes. [Lee MC (2023)]
  • 04B vitamins play a crucial role in maintaining fundamental cellular functions and various essential metabolic pathways in the body. [Lee MC (2023)]
The current Migaku evidence database contains 2 reusable source documents for Vitamin B6 Exercise Fatigue Randomized Trial. This answer focuses on benefits, uncertainty, and practical interpretation. - Based on the evidence presented above, we hypothesized that a 28-day supplementation of vitamin B would enhance physical performance and reduce physical fatigue. [Lee MC (2023); evidence level 2] - After supplementation with Ex PLUS ® , we found a significant increase in the running time by 1.26-fold ( p 0.05) to exhaustion compared to that before supplementation and that in the placebo group. [Lee MC (2023); evidence level 2] - In addition, the Ex PLUS ® supplementation group presented significantly reduced blood lactate and blood ammonia concentrations during exercise and at rest after exercise compared with placebo ( p ® ) supplementation significantly improved exercise endurance performance and reduced exercise fatigue biochemical metabolites in not athletes. [Lee MC (2023); evidence level 2] - B vitamins play a crucial role in maintaining fundamental cellular functions and various essential metabolic pathways in the body. [Lee MC (2023); evidence level 2] - Conclusion: The change of hypoxanthine concentration in sweat can be used as a good biomarker for the diagnosis of exercise-induced fatigue, while the change of pyruvate content in sweat can be used as a discriminant index for the energy metabolism mode of the body before and after exercise. [Meihua S (2023); evidence level 4] Evidence levels are sorting aids, not final clinical grades. Level 1 usually indicates systematic-review style evidence, level 2 indicates randomized trials or public-health guidance, and lower levels need more cautious wording. This page is educational. People with medical conditions, pregnancy, medication use, or unusual symptoms should ask a qualified clinician before changing supplements, medication, or treatment routines.

Sources

  1. A functional evaluation of anti-fatigue and exercise performance improvement following vitamin B complex supplementation in healthy humans, a randomized double-blind trial.
  2. Research on sweat metabolomics of athlete's fatigue induced by high intensity interval training.