What does the evidence say about Tongkat Ali Stress Randomized Trial?

Updated May 2026

Quick Answer

Tongkat Ali Stress Randomized Trial has evidence relevant to benefits, uncertainty, and practical interpretation, but conclusions should stay close to the cited sources. One representative finding is: In general, risk of bias in selective reporting and incomplete data were low, and bias regarding inclusion of intention-to-treat analysis was low to moderate.

Key Takeaways

  • 01In general, risk of bias in selective reporting and incomplete data were low, and bias regarding inclusion of intention-to-treat analysis was low to moderate. [Ho Chao-Yen (2026)]
  • 02The analysis revealed a pooled SMD (pSMD) = 1.20 (95 % confidence interval [CI]: 0.64 to 1.76), indicating that taking herbal dietary supplements was associated with a greater improvement in erectile function as compared to controls. [Ho Chao-Yen (2026)]
  • 03Saffron (pSMD = 2.23, 95 % CI: 1.66 to 2.80) and ginseng (pSMD = 0.41, 95 % CI: 0.20 to 0.62) were each significantly associated with greater improvement in ED compared to that of controls, whereaswas shown to have positive effects on ED compared to controls, but the difference was not statistically significant (pSMD = 0.74, 95 % CI: −0.24 to 1.72). [Ho Chao-Yen (2026)]
  • 04Incidence of ED is reported to increase with increasing age.An estimated 8.3 % of insured men in the United States have been diagnosed with ED, translating to approximately 10.3 million men seeking care for this condition as of 2022. [Ho Chao-Yen (2026)]
The current Migaku evidence database contains 2 reusable source documents for Tongkat Ali Stress Randomized Trial. This answer focuses on benefits, uncertainty, and practical interpretation. - In general, risk of bias in selective reporting and incomplete data were low, and bias regarding inclusion of intention-to-treat analysis was low to moderate. [Ho Chao-Yen (2026); evidence level 1] - The analysis revealed a pooled SMD (pSMD) = 1.20 (95 % confidence interval [CI]: 0.64 to 1.76), indicating that taking herbal dietary supplements was associated with a greater improvement in erectile function as compared to controls. [Ho Chao-Yen (2026); evidence level 1] - Saffron (pSMD = 2.23, 95 % CI: 1.66 to 2.80) and ginseng (pSMD = 0.41, 95 % CI: 0.20 to 0.62) were each significantly associated with greater improvement in ED compared to that of controls, whereaswas shown to have positive effects on ED compared to controls, but the difference was not statistically significant (pSMD = 0.74, 95 % CI: −0.24 to 1.72). [Ho Chao-Yen (2026); evidence level 1] - Incidence of ED is reported to increase with increasing age.An estimated 8.3 % of insured men in the United States have been diagnosed with ED, translating to approximately 10.3 million men seeking care for this condition as of 2022. [Ho Chao-Yen (2026); evidence level 1] - As a result, research on using herbal food supplements as phytochemicals to reduce menopausal symptoms is ongoing all over the world. [Muniandy Subashini (2025); evidence level 4] Evidence levels are sorting aids, not final clinical grades. Level 1 usually indicates systematic-review style evidence, level 2 indicates randomized trials or public-health guidance, and lower levels need more cautious wording. This page is educational. People with medical conditions, pregnancy, medication use, or unusual symptoms should ask a qualified clinician before changing supplements, medication, or treatment routines.

Sources

  1. Herbal dietary supplements for erectile dysfunction: A systematic review and meta-analysis of randomized-controlled trials
  2. Effect of Eurycoma longifolia water extract (Physta ® ) on menopausal quality of life and mood states