Does Saffron Supplementation Mood Randomized Trial work?

The current Migaku evidence database contains 2 reusable source documents for Saffron Supplementation Mood Randomized Trial. This answer focuses on strength of evidence and what the studies can or cannot prove. - Saffron was also associated with greater improvements in self-esteem (adjusted mean difference: 1.43; 95% CI: 0.22, 2.64; d = 0.51; p = 0.022) and sleep-related impairment (adjusted mean difference: 2.99; 95% CI: 0.12, 5.86; d = 0.45; p = 0.041). [Lopresti AL (2026); evidence level 2] - Conclusion Supplementation with a saffron extract (Affron®) for 12 weeks was associated with improvements in depressive symptoms. [Lopresti AL (2026); evidence level 2] - Background Depression is commonly accompanied by sleep disturbances and low self-esteem. [Lopresti AL (2026); evidence level 2] - Saffron ( Crocus sativus L.) has demonstrated antidepressant and sleep-enhancing effects in previous clinical trials; however, its efficacy in women experiencing both low mood and poor sleep has not been specifically examined. [Lopresti AL (2026); evidence level 2] - Behavioral analysis revealed that cold stress significantly impaired memory and increased anxiety-like behavior, whereas oral supplementation of saffron extract reduced anxiety, improved spontaneous alternation and enhanced object recognition memory. [Priya V (2026); evidence level 4] Evidence levels are sorting aids, not final clinical grades. Level 1 usually indicates systematic-review style evidence, level 2 indicates randomized trials or public-health guidance, and lower levels need more cautious wording. This page is educational. People with medical conditions, pregnancy, medication use, or unusual symptoms should ask a qualified clinician before changing supplements, medication, or treatment routines.