What does the evidence say about Phosphatidylserine Exercise Stress Randomized Trial?

Updated October 2026

Quick Answer

Phosphatidylserine Exercise Stress Randomized Trial has evidence relevant to benefits, uncertainty, and practical interpretation, but conclusions should stay close to the cited sources. One representative finding is: Conclusions Under the present 14-day experimental conditions, the multi-ingredient protocols containing taurine, caffeine, and phosphatidylserine were associated with more favorable selected cognitive and psychomotor outcomes, 30 m sprint performance, and baseline-adjusted GPS-derived locomotor outcomes than placebo.

Key Takeaways

  • 01Conclusions Under the present 14-day experimental conditions, the multi-ingredient protocols containing taurine, caffeine, and phosphatidylserine were associated with more favorable selected cognitive and psychomotor outcomes, 30 m sprint performance, and baseline-adjusted GPS-derived locomotor outcomes than placebo. [Mizera K (2026)]
  • 02Background/objectives Cognitive fatigue and impaired psychomotor function may contribute to reductions in football-specific performance during prolonged match-like activity. [Mizera K (2026)]
  • 03This study evaluated cognitive, psychomotor, sprint, and football-specific locomotor responses to multi-ingredient protocols containing taurine, caffeine, and either 300 or 600 mg·day -1 of phosphatidylserine in professional male football players. [Mizera K (2026)]
  • 04However, evidence on multi-ingredient protocols combining taurine, caffeine, and phosphatidylserine (PS) remains limited in professional athletes. [Mizera K (2026)]
The current Migaku evidence database contains 2 reusable source documents for Phosphatidylserine Exercise Stress Randomized Trial. This answer focuses on benefits, uncertainty, and practical interpretation. - Conclusions Under the present 14-day experimental conditions, the multi-ingredient protocols containing taurine, caffeine, and phosphatidylserine were associated with more favorable selected cognitive and psychomotor outcomes, 30 m sprint performance, and baseline-adjusted GPS-derived locomotor outcomes than placebo. [Mizera K (2026); evidence level 2] - Background/objectives Cognitive fatigue and impaired psychomotor function may contribute to reductions in football-specific performance during prolonged match-like activity. [Mizera K (2026); evidence level 2] - This study evaluated cognitive, psychomotor, sprint, and football-specific locomotor responses to multi-ingredient protocols containing taurine, caffeine, and either 300 or 600 mg·day -1 of phosphatidylserine in professional male football players. [Mizera K (2026); evidence level 2] - However, evidence on multi-ingredient protocols combining taurine, caffeine, and phosphatidylserine (PS) remains limited in professional athletes. [Mizera K (2026); evidence level 4] - Results : Compared with placebo, the TCP group was associated with more favorable physical, cognitive, and selected game-related outcomes ( p 2 = 0.13-0.20) and smaller fatigue-related declines in sprint performance (-18% vs. [Mizera K (2026); evidence level 4] Evidence levels are sorting aids, not final clinical grades. Level 1 usually indicates systematic-review style evidence, level 2 indicates randomized trials or public-health guidance, and lower levels need more cautious wording. This page is educational. People with medical conditions, pregnancy, medication use, or unusual symptoms should ask a qualified clinician before changing supplements, medication, or treatment routines.

Sources

  1. Football-Specific Performance and Cognitive Fatigue Resistance Following Supplementation with Two Phosphatidylserine Doses Combined with Taurine and Caffeine in Professional Male Football Players: A Randomized, Triple-Masked, Placebo-Controlled Trial.
  2. Effects of Taurine-, Caffeine-, and Phosphatidylserine-Containing Supplementation Protocols on Physical and Cognitive Performance in Professional Male Football Players.