Is Milk Thistle Liver Wellness Randomized Trial safe?

The current Migaku evidence database contains 2 reusable source documents for Milk Thistle Liver Wellness Randomized Trial. This answer focuses on safety, limits, and clinician-discussion contexts. - We aimed to investigate the hepatoprotective effect of Heptex® capsules containing 200 mg of Dukung Anak (a powdered extract from aerial parts of Phyllanthus niruri) and 100 mg of Milk Thistle (a powdered extract from fruits of Silybum marianum) in patients with an apparent risk factor for NASH. [Shaker MK (2025); evidence level 2] - A significant decrease was observed in ALT levels in the low-dose group (57 IU/L to 40 IU/L, p = 0.026) and the high-dose group (61 IU/L to 47.5 IU/L, p Conclusion Heptex® capsules were safe and well tolerated over a treatment period of 36 weeks. [Shaker MK (2025); evidence level 2] - However, the hepatoprotective effect in patients at risk of NASH still needs further assessment using more accurate investigation tools, a larger sample size, and/ or higher doses of the combination. [Shaker MK (2025); evidence level 2] - Background Nonalcoholic steatohepatitis (NASH) is a severe form of nonalcoholic fatty liver disease (NAFLD) characterized by damage and inflammation of hepatocytes. [Shaker MK (2025); evidence level 2] - MASLD (Metabolic Dysfunction-Associated Steatotic Liver Disease) is a growing global concern. [Vrentzos E (2025); evidence level 4] Evidence levels are sorting aids, not final clinical grades. Level 1 usually indicates systematic-review style evidence, level 2 indicates randomized trials or public-health guidance, and lower levels need more cautious wording. This page is educational. People with medical conditions, pregnancy, medication use, or unusual symptoms should ask a qualified clinician before changing supplements, medication, or treatment routines.