Quick Answer
Marine Collagen Skin Meta-Analysis has evidence relevant to benefits, uncertainty, and practical interpretation, but conclusions should stay close to the cited sources. One representative finding is: In HUVECs, GAE increased viability, migration, tube formation, and vascular endothelial growth factor (VEGF) expression.
Key Takeaways
- 01In HUVECs, GAE increased viability, migration, tube formation, and vascular endothelial growth factor (VEGF) expression. [Jeong S (2026)]
- 02In mice, GAE accelerated wound closure from day 3 to day 5 and increased granulation/matrix with higher proliferating cell nuclear antigen (PCNA) and cluster of differentiation 31 (CD31) expression after a single topical application. [Jeong S (2026)]
- 03In addition, keratin 14 (K14) expression was restored in GAE-treated wound tissues, suggesting improved epidermal re-epithelialization. [Jeong S (2026)]
- 04Marine red algae have been reported to contain a variety of bioactive compounds that are effective in promoting wound-healing processes. [Jeong S (2026)]
The current Migaku evidence database contains 1 reusable source document for Marine Collagen Skin Meta-Analysis. This answer focuses on benefits, uncertainty, and practical interpretation.
- In HUVECs, GAE increased viability, migration, tube formation, and vascular endothelial growth factor (VEGF) expression. [Jeong S (2026); evidence level 4]
- In mice, GAE accelerated wound closure from day 3 to day 5 and increased granulation/matrix with higher proliferating cell nuclear antigen (PCNA) and cluster of differentiation 31 (CD31) expression after a single topical application. [Jeong S (2026); evidence level 4]
- In addition, keratin 14 (K14) expression was restored in GAE-treated wound tissues, suggesting improved epidermal re-epithelialization. [Jeong S (2026); evidence level 4]
- Marine red algae have been reported to contain a variety of bioactive compounds that are effective in promoting wound-healing processes. [Jeong S (2026); evidence level 4]
Evidence levels are sorting aids, not final clinical grades. Level 1 usually indicates systematic-review style evidence, level 2 indicates randomized trials or public-health guidance, and lower levels need more cautious wording.
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Sources