Is L-Citrulline Resistance Training Meta-Analysis safe?

The current Migaku evidence database contains 2 reusable source documents for L-Citrulline Resistance Training Meta-Analysis. This answer focuses on safety, limits, and clinician-discussion contexts. - Conclusion Chronic citrulline supplementation seems to enhance upper body muscular endurance and post-exercise NO X response to RT, but there is no apparent difference between LC and CM in these aspects. [Bayat D (2025); evidence level 2] - Purpose This study aimed to investigate and compare the effects of chronic supplementation with L-Citrulline (LC) vs. [Bayat D (2025); evidence level 2] - Methods Thirty-three resistance-trained men were randomly assigned to ingest LC (8 g), CM (12 g), or Placebo (PL) daily, along with participation in a 6-week RT protocol. [Bayat D (2025); evidence level 2] - Endothelial dysfunction is associated with hypertension and the age-related decreases in muscle mass and strength. [Kang Y (2022); evidence level 4] - L-citrulline supplementation (CIT) and slow velocity low-intensity resistance training (SVLIRT) have improved vascular function, but their effect on muscle mass is unclear. [Kang Y (2022); evidence level 4] Evidence levels are sorting aids, not final clinical grades. Level 1 usually indicates systematic-review style evidence, level 2 indicates randomized trials or public-health guidance, and lower levels need more cautious wording. This page is educational. People with medical conditions, pregnancy, medication use, or unusual symptoms should ask a qualified clinician before changing supplements, medication, or treatment routines.