Is L-Citrulline Endurance Exercise Meta-Analysis safe?

The current Migaku evidence database contains 2 reusable source documents for L-Citrulline Endurance Exercise Meta-Analysis. This answer focuses on safety, limits, and clinician-discussion contexts. - Risk of bias, small-study effects, sensitivity analyses, and GRADE certainty were assessed. [Wang X (2026); evidence level 1] - CM supplementation was associated with a small improvement in overall exercise performance (g = 0.16, p = 0.01); however, prediction intervals were wide and statistical power was limited. [Wang X (2026); evidence level 1] - Current evidence appeared more stable for acute than chronic supplementation, although the protocol subgroup difference remained uncertain. [Wang X (2026); evidence level 1] - Background: Citrulline malate (CM) is commonly used as an ergogenic supplement, but its effects on exercise performance and perceived exertion remain uncertain. [Wang X (2026); evidence level 1] - Next, we integrate evidence on the ergogenic effects of various dietary interventions with existing knowledge on the perception of effort. [Strasser B (2026); evidence level 4] Evidence levels are sorting aids, not final clinical grades. Level 1 usually indicates systematic-review style evidence, level 2 indicates randomized trials or public-health guidance, and lower levels need more cautious wording. This page is educational. People with medical conditions, pregnancy, medication use, or unusual symptoms should ask a qualified clinician before changing supplements, medication, or treatment routines.