Quick Answer
Holy Basil Anxiety Randomized Trial has evidence relevant to safety, limits, and clinician-discussion contexts, but conclusions should stay close to the cited sources. One representative finding is: Results At day 60, both VL-G-A57 and VL-G-E12 significantly reduced Perceived Stress Scale (PSS) scores compared to placebo (p Conclusion The study concluded that both VL-G-A57 and VL-G-E12 were associated with reductions in stress, fatigue, and anxiety while improving mood and sleep quality.
Key Takeaways
- 01Results At day 60, both VL-G-A57 and VL-G-E12 significantly reduced Perceived Stress Scale (PSS) scores compared to placebo (p Conclusion The study concluded that both VL-G-A57 and VL-G-E12 were associated with reductions in stress, fatigue, and anxiety while improving mood and sleep quality. [McKinney E (2026)]
- 02Background Chronic stress is detrimental to the maintenance of the main response system - the hypothalamic-pituitary-adrenal (HPA) axis. [McKinney E (2026)]
- 03The current study aimed to investigate the efficacy of two plant-based adaptogens, a formula containing Rhodiola, holy basil and Schisandra chinensis (VL-G-A57) and a full-spectrum ashwagandha (VL-G-E12), on stress and related symptoms in individuals with high stress. [McKinney E (2026)]
- 04Depression can affect thoughts, mood, and physical health and can be associated with numerous symptoms such as low mood, fatigue, sadness, insomnia, anhedonia, and cognitive impairment symptoms (Li et al.; Schulz and Arora). [Talaei Mahva (2025)]
The current Migaku evidence database contains 2 reusable source documents for Holy Basil Anxiety Randomized Trial. This answer focuses on safety, limits, and clinician-discussion contexts.
- Results At day 60, both VL-G-A57 and VL-G-E12 significantly reduced Perceived Stress Scale (PSS) scores compared to placebo (p Conclusion The study concluded that both VL-G-A57 and VL-G-E12 were associated with reductions in stress, fatigue, and anxiety while improving mood and sleep quality. [McKinney E (2026); evidence level 2]
- Background Chronic stress is detrimental to the maintenance of the main response system - the hypothalamic-pituitary-adrenal (HPA) axis. [McKinney E (2026); evidence level 2]
- The current study aimed to investigate the efficacy of two plant-based adaptogens, a formula containing Rhodiola, holy basil and Schisandra chinensis (VL-G-A57) and a full-spectrum ashwagandha (VL-G-E12), on stress and related symptoms in individuals with high stress. [McKinney E (2026); evidence level 2]
- Depression can affect thoughts, mood, and physical health and can be associated with numerous symptoms such as low mood, fatigue, sadness, insomnia, anhedonia, and cognitive impairment symptoms (Li et al.; Schulz and Arora). [Talaei Mahva (2025); evidence level 2]
- Anxiety disorders are the most common associated disorders in depressed patients. [Talaei Mahva (2025); evidence level 2]
Evidence levels are sorting aids, not final clinical grades. Level 1 usually indicates systematic-review style evidence, level 2 indicates randomized trials or public-health guidance, and lower levels need more cautious wording.
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