Quick Answer
Fennel Constipation Randomized Trial has evidence relevant to safety, limits, and clinician-discussion contexts, but conclusions should stay close to the cited sources. One representative finding is: NSAIDs have been found to be more effective than placebo in relieving pain in women with primary dysmenorrhea, but they increase the risk of adverse effects, such as mild neurological symptoms (headache, drowsiness, dizziness) and gastrointestinal symptoms (nausea, indigestion).
Key Takeaways
- 01NSAIDs have been found to be more effective than placebo in relieving pain in women with primary dysmenorrhea, but they increase the risk of adverse effects, such as mild neurological symptoms (headache, drowsiness, dizziness) and gastrointestinal symptoms (nausea, indigestion). [Ma Wenyi (2026)]
- 02However, when combined OCP is used, there is an additional deep vein thrombosis (DVT) in every 1,000 women, and a higher risk is observed in users aged 6–12 months before use and over 40 years old (). [Ma Wenyi (2026)]
- 03In addition to the known thrombotic effect of estrogen, the type of progesterone may also affect the risk of DVT, although the data are limited and contradictory (–). [Ma Wenyi (2026)]
- 041 2 Figure 1 Primary dysmenorrhea is a menstrual disorder characterized by pain that begins shortly before or at the onset of menstruation and can last up to 72 h. [Ma Wenyi (2026)]
The current Migaku evidence database contains 2 reusable source documents for Fennel Constipation Randomized Trial. This answer focuses on safety, limits, and clinician-discussion contexts.
- NSAIDs have been found to be more effective than placebo in relieving pain in women with primary dysmenorrhea, but they increase the risk of adverse effects, such as mild neurological symptoms (headache, drowsiness, dizziness) and gastrointestinal symptoms (nausea, indigestion). [Ma Wenyi (2026); evidence level 3]
- However, when combined OCP is used, there is an additional deep vein thrombosis (DVT) in every 1,000 women, and a higher risk is observed in users aged 6–12 months before use and over 40 years old (). [Ma Wenyi (2026); evidence level 3]
- In addition to the known thrombotic effect of estrogen, the type of progesterone may also affect the risk of DVT, although the data are limited and contradictory (–). [Ma Wenyi (2026); evidence level 3]
- 1 2 Figure 1 Primary dysmenorrhea is a menstrual disorder characterized by pain that begins shortly before or at the onset of menstruation and can last up to 72 h. [Ma Wenyi (2026); evidence level 3]
- Moreover, limited evidence exists regarding herb-drug interactions and long-term safety profiles. [Abalo R (2025); evidence level 3]
Evidence levels are sorting aids, not final clinical grades. Level 1 usually indicates systematic-review style evidence, level 2 indicates randomized trials or public-health guidance, and lower levels need more cautious wording.
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Sources