topicFennel Constipation Randomized Trial
claimNSAIDs have been found to be more effective than placebo in relieving pain in women with primary dysmenorrhea, but they increase the risk of adverse effects, such as mild neurological symptoms (headache, drowsiness, dizziness) and gastrointestinal symptoms (nausea, indigestion).
evidence level3
citationMa Wenyi (2026)
sourceComplementary and alternative therapies in the treatment of primary dysmenorrhea
topicFennel Constipation Randomized Trial
claimHowever, when combined OCP is used, there is an additional deep vein thrombosis (DVT) in every 1,000 women, and a higher risk is observed in users aged 6–12 months before use and over 40 years old ().
evidence level3
citationMa Wenyi (2026)
sourceComplementary and alternative therapies in the treatment of primary dysmenorrhea
topicFennel Constipation Randomized Trial
claimIn addition to the known thrombotic effect of estrogen, the type of progesterone may also affect the risk of DVT, although the data are limited and contradictory (–).
evidence level3
citationMa Wenyi (2026)
sourceComplementary and alternative therapies in the treatment of primary dysmenorrhea
topicFennel Constipation Randomized Trial
claim1 2 Figure 1 Primary dysmenorrhea is a menstrual disorder characterized by pain that begins shortly before or at the onset of menstruation and can last up to 72 h.
evidence level3
citationMa Wenyi (2026)
sourceComplementary and alternative therapies in the treatment of primary dysmenorrhea
topicFennel Constipation Randomized Trial
claimMoreover, limited evidence exists regarding herb-drug interactions and long-term safety profiles.
evidence level3
citationAbalo R (2025)
sourceNatural Remedies for Irritable Bowel Syndrome: A Comprehensive Review of Herbal-Based Therapies.
topicFennel Constipation Randomized Trial
claimIrritable Bowel Syndrome (IBS) is a complex and multifactorial gastrointestinal disorder characterized by recurrent abdominal pain and altered bowel habits, impacting quality of life.
evidence level3
citationAbalo R (2025)
sourceNatural Remedies for Irritable Bowel Syndrome: A Comprehensive Review of Herbal-Based Therapies.
topicFennel Constipation Randomized Trial
claimTherapy is mainly based on relieving symptoms with specific drugs, whereas herbal and complementary remedies have gained attention in recent years.
evidence level3
citationAbalo R (2025)
sourceNatural Remedies for Irritable Bowel Syndrome: A Comprehensive Review of Herbal-Based Therapies.