Is Citrulline Exercise Fatigue Randomized Trial safe?

The current Migaku evidence database contains 2 reusable source documents for Citrulline Exercise Fatigue Randomized Trial. This answer focuses on safety, limits, and clinician-discussion contexts. - Strategies that support repeated high-intensity sprint performance are of considerable interest in competitive sprinting and team sports; however, evidence regarding acute citrulline malate (CM) supplementation during recovery intervals remains limited. [Yamanaka R (2026); evidence level 2] - This study examined the effects of acute CM supplementation on repeated 100 m sprint performance and rating of perceived exertion (RPE) in trained sprinters. [Yamanaka R (2026); evidence level 2] - Individual exercise tolerance is defined as the amount of physical exertion that can be sustained before task disengagement and can be increased through appropriate training strategies [,]. [Strasser Barbara (2026); evidence level 4] - We then integrate evidence on the ergogenic effects of various dietary interventions with existing knowledge on perception of effort, focusing on how these interventions may limit the development of fatigue during endurance exercise and thereby influence effort perception. [Strasser Barbara (2026); evidence level 4] - Such adjustments result in impaired time trial performance when perceived effort rises [], and improved performance when perceived effort is reduced []. [Strasser Barbara (2026); evidence level 4] Evidence levels are sorting aids, not final clinical grades. Level 1 usually indicates systematic-review style evidence, level 2 indicates randomized trials or public-health guidance, and lower levels need more cautious wording. This page is educational. People with medical conditions, pregnancy, medication use, or unusual symptoms should ask a qualified clinician before changing supplements, medication, or treatment routines.