Quick Answer
Citrulline Endurance Randomized Trial has evidence relevant to strength of evidence and what the studies can or cannot prove, but conclusions should stay close to the cited sources. One representative finding is: This involves addressing the effects of high‐intensity exercise, including increased glycolysis, blood lactate accumulation, fatigue, muscle soreness, local inflammation, and oxidative stress (MacIntyre et al. ; Mutch and Banister ; Zerba et al. ).
Key Takeaways
- 01This involves addressing the effects of high‐intensity exercise, including increased glycolysis, blood lactate accumulation, fatigue, muscle soreness, local inflammation, and oxidative stress (MacIntyre et al. ; Mutch and Banister ; Zerba et al. ). [Norouzzadeh Mostafa (2025)]
- 02Studies have indicated that supplementation with watermelon juice before exercise in male runners resulted in improved exercise strength, reduced perceived exertion and muscle soreness after exercise, and decreased plasma lactate concentrations in resistance‐trained males (Martínez‐Sánchez, Alacid, et al. ; Martínez‐Sánchez, Ramos‐Campo, et al. ). [Norouzzadeh Mostafa (2025)]
- 03showed that acute watermelon juice (1.2 g of L‐citrulline) or enriched watermelon juice (6 g L‐citrulline) supplementation reduced muscle soreness but did not improve performance in untrained individuals (Tarazona‐Díaz et al. ). [Norouzzadeh Mostafa (2025)]
- 042016 1996 1983 1990 1991 2006 2002 Scientists are working towards developing a highly effective method to optimize exercise performance (Yan et al. ). [Norouzzadeh Mostafa (2025)]
The current Migaku evidence database contains 2 reusable source documents for Citrulline Endurance Randomized Trial. This answer focuses on strength of evidence and what the studies can or cannot prove.
- This involves addressing the effects of high‐intensity exercise, including increased glycolysis, blood lactate accumulation, fatigue, muscle soreness, local inflammation, and oxidative stress (MacIntyre et al. ; Mutch and Banister ; Zerba et al. ). [Norouzzadeh Mostafa (2025); evidence level 2]
- Studies have indicated that supplementation with watermelon juice before exercise in male runners resulted in improved exercise strength, reduced perceived exertion and muscle soreness after exercise, and decreased plasma lactate concentrations in resistance‐trained males (Martínez‐Sánchez, Alacid, et al. ; Martínez‐Sánchez, Ramos‐Campo, et al. ). [Norouzzadeh Mostafa (2025); evidence level 2]
- showed that acute watermelon juice (1.2 g of L‐citrulline) or enriched watermelon juice (6 g L‐citrulline) supplementation reduced muscle soreness but did not improve performance in untrained individuals (Tarazona‐Díaz et al. ). [Norouzzadeh Mostafa (2025); evidence level 2]
- 2016 1996 1983 1990 1991 2006 2002 Scientists are working towards developing a highly effective method to optimize exercise performance (Yan et al. ). [Norouzzadeh Mostafa (2025); evidence level 2]
- Through its involvement in NO-related pathways, L-ARG supplementation has been associated with changes in vascular function and blood flow, which may influence exercise-related physiological responses (,–). [Uçar Halil (2026); evidence level 4]
Evidence levels are sorting aids, not final clinical grades. Level 1 usually indicates systematic-review style evidence, level 2 indicates randomized trials or public-health guidance, and lower levels need more cautious wording.
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Sources
- The Effects of Watermelon Juice on Muscle Hypertrophy, Exercise Performance, and Muscle Soreness in Non‐Athlete Men Undergoing Endurance Training: A Randomized Controlled Trial
- Acute effects of citrulline malate and L-arginine, alone and in combination, on anaerobic performance indicators in highly trained taekwondo athletes