What does the evidence say about Citrulline Endurance Performance Meta-Analysis?

Updated May 2026

Quick Answer

Citrulline Endurance Performance Meta-Analysis has evidence relevant to benefits, uncertainty, and practical interpretation, but conclusions should stay close to the cited sources. One representative finding is: Through its involvement in NO-related pathways, L-ARG supplementation has been associated with changes in vascular function and blood flow, which may influence exercise-related physiological responses (,–).

Key Takeaways

  • 01Through its involvement in NO-related pathways, L-ARG supplementation has been associated with changes in vascular function and blood flow, which may influence exercise-related physiological responses (,–). [Uçar Halil (2026)]
  • 02However, the findings across these studies remain inconsistent, and conclusive evidence supporting clear performance or recovery benefits has yet to be established. [Uçar Halil (2026)]
  • 03No significant sequence effect was detected (= 1.08,= 0.393, ηp= 0.213), and no significant period × sequence interaction was observed (= 1.04,= 0.430, ηp= 0.206), indicating no statistically significant evidence of meaningful carryover effects and supporting the adequacy of the 72-h washout period. [Uçar Halil (2026)]
  • 041 2 3 Taekwondo is a full-contact martial art in which successful performance is largely determined by the execution of high-force kicking techniques directed to the trunk protector or head of the opponent (,). [Uçar Halil (2026)]
The current Migaku evidence database contains 2 reusable source documents for Citrulline Endurance Performance Meta-Analysis. This answer focuses on benefits, uncertainty, and practical interpretation. - Through its involvement in NO-related pathways, L-ARG supplementation has been associated with changes in vascular function and blood flow, which may influence exercise-related physiological responses (,–). [Uçar Halil (2026); evidence level 4] - However, the findings across these studies remain inconsistent, and conclusive evidence supporting clear performance or recovery benefits has yet to be established. [Uçar Halil (2026); evidence level 4] - No significant sequence effect was detected (= 1.08,= 0.393, ηp= 0.213), and no significant period × sequence interaction was observed (= 1.04,= 0.430, ηp= 0.206), indicating no statistically significant evidence of meaningful carryover effects and supporting the adequacy of the 72-h washout period. [Uçar Halil (2026); evidence level 4] - 1 2 3 Taekwondo is a full-contact martial art in which successful performance is largely determined by the execution of high-force kicking techniques directed to the trunk protector or head of the opponent (,). [Uçar Halil (2026); evidence level 4] - This narrative review synthesizes evidence on naturally derived compounds that influence these pathways, including guayusa, guarana, Alpinia galanga , theobromine, L-citrulline, beetroot extract, cordyceps, and niacin, as well as natural sweeteners such as monk fruit and stevia. [Panda R (2026); evidence level 4] Evidence levels are sorting aids, not final clinical grades. Level 1 usually indicates systematic-review style evidence, level 2 indicates randomized trials or public-health guidance, and lower levels need more cautious wording. This page is educational. People with medical conditions, pregnancy, medication use, or unusual symptoms should ask a qualified clinician before changing supplements, medication, or treatment routines.

Sources

  1. Acute effects of citrulline malate and L-arginine, alone and in combination, on anaerobic performance indicators in highly trained taekwondo athletes
  2. Synergistic Actions of Natural Compounds for Enhancing Cognitive and Physical Performance: A Narrative Review.